Over‐expression of short isoforms of Helios in patients with adult T‐cell leukaemia/lymphoma

In previous studies, we demonstrated an over‐expression of the dominant‐negative isoform of the transcription factor Ikaros in patients with blast crisis of both chronic myelogenous leukaemia and B‐cell acute lymphoblastic leukaemia (ALL). Recently, we reported an over‐expression of the short isofor...

Full description

Saved in:
Bibliographic Details
Published in:British journal of haematology 2003-03, Vol.120 (6), p.986-989
Main Authors: Fujii, Keiko, Ishimaru, Fumihiko, Nakase, Koichi, Tabayashi, Takayuki, Kozuka, Teruhiko, Naoki, Kyoko, Miyahara, Masayuki, Toki, Hironobu, Kitajima, Koichi, Harada, Mine, Tanimoto, Mitsune
Format: Article
Language:English
Subjects:
adult T‐cell leukaemia/lymphoma
Aiolos
Biological and medical sciences
Blotting, Southern
Carrier State
Disease Progression
DNA-Binding Proteins - genetics
Gene Deletion
Helios
Hematologic and hematopoietic diseases
Hematology
HTLV-I Infections - genetics
Humans
Ikaros
Ikaros Transcription Factor
Leukemia-Lymphoma, Adult T-Cell - metabolism
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Protein Isoforms - genetics
Reverse Transcriptase Polymerase Chain Reaction
short isoform
Transcription Factors - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In previous studies, we demonstrated an over‐expression of the dominant‐negative isoform of the transcription factor Ikaros in patients with blast crisis of both chronic myelogenous leukaemia and B‐cell acute lymphoblastic leukaemia (ALL). Recently, we reported an over‐expression of the short isoforms of Helios, which is one of the members of the Ikaros gene family, in a patient with T‐cell ALL. In the present study, we found over‐expression of short isoforms of Helios in human T lymphotropic virus‐I (HTLV1)‐infected patients who had developed chronic and acute forms of adult T‐cell leukaemia/lymphoma. In contrast, we could not detect any over‐expression of short isoforms of Helios in healthy HTLV1 carriers. By Southern blotting, we detected a small deletion in the Helios gene locus of adult T‐cell leukaemia/lymphoma patients. The present results suggest that Helios gene abnormalities might be one of the important mechanisms in the disease progression of HTLV1 infection.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2003.04216.x