alpha1- and alpha2-adrenergic vasoconstriction is blunted in contracting human muscle

Sympathetic vasoconstriction is blunted in the vascular beds of contracting skeletal muscles. We sought to determine whether this blunted vasoconstriction is specific for post-junctional alpha1- or alpha2-adrenergic receptors. We measured forearm blood flow (Doppler ultrasound) and calculated the va...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of physiology 2003-03, Vol.547 (Pt 3), p.971-976
Main Authors: Rosenmeier, Jaya B, Dinenno, Frank A, Fritzlar, Sandy J, Joyner, Michael J
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - administration & dosage
Adrenergic Uptake Inhibitors - administration & dosage
Adult
Clonidine - administration & dosage
Forearm - blood supply
Humans
Male
Muscle Contraction - physiology
Muscle, Skeletal - blood supply
Muscle, Skeletal - physiology
Phenylephrine - administration & dosage
Receptors, Adrenergic, alpha-1 - metabolism
Receptors, Adrenergic, alpha-2 - metabolism
Tyramine - administration & dosage
Vasoconstriction - drug effects
Vasoconstriction - physiology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sympathetic vasoconstriction is blunted in the vascular beds of contracting skeletal muscles. We sought to determine whether this blunted vasoconstriction is specific for post-junctional alpha1- or alpha2-adrenergic receptors. We measured forearm blood flow (Doppler ultrasound) and calculated the vascular conductance (FVC) responses to brachial artery infusions of tyramine (which evokes endogenous noradrenaline release), phenylephrine (an alpha1 agonist) and clonidine (an alpha2 agonist) in 10 healthy men during rhythmic handgrip exercise (10-15 % of maximum) and during a control non-exercise vasodilator condition (intra-arterial adenosine). Steady-state FVC during exercise and adenosine was similar in all trials (range: 243-272 and 234-263 ml min-1 (100 mmHg)-1, respectively; P > 0.5). During exercise the percentage reductions in FVC in response to tyramine (-24 +/- 7 vs. -55 +/- 6 %), phenylephrine (-12 +/- 8 vs. -37 +/- 8 %) and clonidine (-17 +/- 6 vs. -49 +/- 4 %) were significantly less compared with adenosine (all P < 0.05). The magnitude of the blunted vasoconstrictor responses was similar for both receptor subtypes. These findings are in contrast to those from studies in animals demonstrating that alpha2-adrenergic receptor-mediated vasoconstrictor responses are much more sensitive to contraction-induced inhibition than alpha1-mediated responses. We conclude that vasoconstrictor responses mediated via both post-junctional alpha1- and alpha2-adrenergic receptors are blunted in contracting human skeletal muscles.
ISSN:0022-3751