Neutrophil and Lymphocyte Response to Supplementation with Vitamins C and E in Young Calves

Calves, beginning at 3 d of age, were bottle-fed milk replacer unsupplemented, or supplemented with 10 g of vitamin C, or supplemented with 10 g of vitamin C plus 57 IU of vitamin E/kg of dry milk replacer (10 calves per treatment). Neutrophils from wk 2 and 4 blood samples were assayed for Staphylo...

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Bibliographic Details
Published in:Journal of dairy science 1992-06, Vol.75 (6), p.1635-1642
Main Authors: Eicher-Pruiett, S. D, Morrill, J. L, Blecha, F, Higgins, J. J, Anderson, N. V, Reddy, P. G
Format: Article
Language:English
Subjects:
Animals
Antibody-Dependent Cell Cytotoxicity - drug effects
Ascorbic Acid - blood
Ascorbic Acid - pharmacology
Biological and medical sciences
Cattle - growth & development
Cattle - immunology
Feed and pet food industries
Food industries
Fundamental and applied biological sciences. Psychology
Immunity, Cellular - drug effects
Lymphocyte Activation - drug effects
Lymphocytes - drug effects
Lymphocytes - immunology
Male
Neutrophils - drug effects
Neutrophils - immunology
Vitamin E - blood
Vitamin E - pharmacology
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Summary:Calves, beginning at 3 d of age, were bottle-fed milk replacer unsupplemented, or supplemented with 10 g of vitamin C, or supplemented with 10 g of vitamin C plus 57 IU of vitamin E/kg of dry milk replacer (10 calves per treatment). Neutrophils from wk 2 and 4 blood samples were assayed for Staphylococcus aureus phagocytosis and neutrophil-mediated, antibody-dependent cellular cytotoxicity, and lymphocytes from those samples were assayed for concanavalin A-induced, phytohemagglutinin-induced, or pokeweed mitogen-induced proliferation. Ocular and nasal discharges of calves supplemented with vitamins C or C and E were less than those of controls for wk 1 to 8. Calves receiving supplementation with vitamin C and E tended to have higher mitogen-induced lymphocyte proliferative responses at wk 2. Neutrophil-mediated phagocytosis and antibody-dependent cellular cytotoxicity were lower at wk 2 and 4 for calves supplemented with vitamin C than for controls. Neutrophil function of calves supplemented with vitamins C and E together was near, or slightly higher than, that of unsupplemented calves for wk 2 and 4, suggesting that the addition of vitamin E negated the adverse effects that vitamin C alone had on neutrophil functions.
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.S0022-0302(92)77920-X