MERSACIDIN, A NEW ANTIBIOTIC FROM BACILLUS: IN VITRO AND IN VIVO ANTIBACTERIAL ACTIVITY

Mersacidin is a new peptide antibiotic of the proposed lantibiotic family. It is active in vitro and in vivo against Gram-positive bacteria including the methicillin-resistant Staphylococci. Its in vitro activity is less than those of vancomycin and erythromycin but it shows much higher activity in...

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Bibliographic Details
Published in:Journal of antibiotics 1992/06/25, Vol.45(6), pp.839-845
Main Authors: CHATTERJEE, SUKUMAR, CHATTERJEE, DIPAK KUMAR, JANI, RAJENDRA H., BLUMBACH, J., GANGULI, B. N., KLESEL, NORBERT, LIMBERT, MICHAEL, SEIBERT, GERHARD
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacillus
Bacteria - drug effects
Bacteriocins
Biological and medical sciences
Female
Male
Medical sciences
Methicillin Resistance
Mice
Peptides - pharmacology
Pharmacology. Drug treatments
Staphylococcus - drug effects
Streptococcus pyogenes - drug effects
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Summary:Mersacidin is a new peptide antibiotic of the proposed lantibiotic family. It is active in vitro and in vivo against Gram-positive bacteria including the methicillin-resistant Staphylococci. Its in vitro activity is less than those of vancomycin and erythromycin but it shows much higher activity in the in vivo system than can be expected from the in vitro testing results. A water soluble potassium salt has been prepared which has an activity profile similar to that of mersacidin, but has better in vivo activity against Streptococcus pyogenes than the parent compound.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.839