A role of the Duffy antigen for the maintenance of plasma chemokine concentrations

• Published in: Biochemical and biophysical research communications 2003-03, Vol.303 (1), p.137-139
• Main Authors: Fukuma, Nobuko, Akimitsu, Nobuyoshi, Hamamoto, Hiroshi, Kusuhara, Hiroyuki, Sugiyama, Yuichi, Sekimizu, Kazuhisa
• Format: Article
• Language: English
• Subjects: Animals; Antigens, Protozoan; Carrier Proteins - metabolism; Carrier Proteins - physiology; Chemokine CCL11; Chemokine CXCL1; Chemokine CXCL10; Chemokines - blood; Chemokines - metabolism; Chemokines - pharmacokinetics; Chemokines, CC - blood; Chemokines, CXC - metabolism; Chemotactic Factors - pharmacokinetics; Duffy Blood-Group System - genetics; Intercellular Signaling Peptides and Proteins - pharmacokinetics; Interferon-gamma - pharmacokinetics; Mice; Mice, Knockout; Protozoan Proteins - metabolism; Protozoan Proteins - physiology; Receptors, Cell Surface - metabolism; Receptors, Cell Surface - physiology; Time Factors
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/S0006-291X(03)00293-6

We examined plasma chemokine concentrations and chemokine clearance rates in Duffy antigen knockout mice. The plasma concentrations of eotaxin and MCP-1 in Duffy antigen knockout mice were less than one-third of those in wild-type mice. When eotaxin or hMGSA was intravenously injected, the chemokine disappeared more rapidly from the plasma of Duffy antigen knockout mice than from the plasma of wild-type mice. The half-lives of hIP-10 and interferon-γ, which do not have an affinity for the Duffy antigen, in plasma were indistinguishable between Duffy antigen knockout mice and wild-type mice. These results suggest that the Duffy antigen delays the disappearance of chemokines from the plasma, resulting in the maintenance of plasma chemokine concentrations.