Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent

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Bibliographic Details
Published in:Journal of medicinal chemistry 1992-08, Vol.35 (16), p.3081-3084
Main Authors: Bloom, J D, Dutia, M D, Johnson, B D, Wissner, A, Burns, M G, Largis, E E, Dolan, J A, Claus, T H
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Adrenergic beta-Agonists - metabolism
Adrenergic beta-Agonists - pharmacology
Animals
Diabetes Mellitus, Type 2 - drug therapy
Hypoglycemic Agents - pharmacology
Lipolysis - drug effects
Male
Mice
Mice, Obese
Obesity - drug therapy
Substrate Specificity
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ISSN:0022-2623
DOI:10.1021/jm00094a025