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Turner's syndrome patients lack tight junctions between uterine epithelial cells

Eleven endometrial biopsies, taken from six Turner's syndrome patients receiving hormone replacement therapy prior to treatment by oocyte donation and embryo transfer, were assessed by freeze fracture followed by electron microscopy for epithelial tight junctions. Nine of the eleven biopsies ha...

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Published in:	Human reproduction (Oxford) 1992-07, Vol.7 (6), p.883-885
Main Authors:	Rogers, P. A. W., Murphy, C. R., Leeton, J., Hosie, M. J., Beaton, L.
Format:	Article
Language:	English
Subjects:	Adult Biological and medical sciences Birth control Embryo Transfer endometrium epithelium Epithelium - ultrastructure Female Freeze Fracturing Gynecology. Andrology. Obstetrics Humans Intercellular Junctions - ultrastructure Medical sciences Microscopy, Electron oocyte donation Sterility. Assisted procreation tight junction Turner Syndrome - pathology Turner's syndrome Uterus - ultrastructure
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container_end_page	885
container_issue	6
container_start_page	883
container_title	Human reproduction (Oxford)
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creator	Rogers, P. A. W. Murphy, C. R. Leeton, J. Hosie, M. J. Beaton, L.
description	Eleven endometrial biopsies, taken from six Turner's syndrome patients receiving hormone replacement therapy prior to treatment by oocyte donation and embryo transfer, were assessed by freeze fracture followed by electron microscopy for epithelial tight junctions. Nine of the eleven biopsies had no discernible tight junctions; the other two biopsies had reduced and disorganized junctional structures. Two patients subsequently became pregnant following embryo transfer. It is concluded that compromised epithelial integrity does not prevent embryo implantation in the human, an observation that is consistent with a barrier role for the epithelium except at times when appropriately conditioned with oestrogen and progesterone to induce receptivity for implantation.
doi_str_mv	10.1093/oxfordjournals.humrep.a137754
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It is concluded that compromised epithelial integrity does not prevent embryo implantation in the human, an observation that is consistent with a barrier role for the epithelium except at times when appropriately conditioned with oestrogen and progesterone to induce receptivity for implantation.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/oxfordjournals.humrep.a137754</identifier><identifier>PMID: 1500490</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Biological and medical sciences ; Birth control ; Embryo Transfer ; endometrium ; epithelium ; Epithelium - ultrastructure ; Female ; Freeze Fracturing ; Gynecology. Andrology. Obstetrics ; Humans ; Intercellular Junctions - ultrastructure ; Medical sciences ; Microscopy, Electron ; oocyte donation ; Sterility. 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W.</creatorcontrib><creatorcontrib>Murphy, C. R.</creatorcontrib><creatorcontrib>Leeton, J.</creatorcontrib><creatorcontrib>Hosie, M. J.</creatorcontrib><creatorcontrib>Beaton, L.</creatorcontrib><title>Turner's syndrome patients lack tight junctions between uterine epithelial cells</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>Eleven endometrial biopsies, taken from six Turner's syndrome patients receiving hormone replacement therapy prior to treatment by oocyte donation and embryo transfer, were assessed by freeze fracture followed by electron microscopy for epithelial tight junctions. Nine of the eleven biopsies had no discernible tight junctions; the other two biopsies had reduced and disorganized junctional structures. Two patients subsequently became pregnant following embryo transfer. It is concluded that compromised epithelial integrity does not prevent embryo implantation in the human, an observation that is consistent with a barrier role for the epithelium except at times when appropriately conditioned with oestrogen and progesterone to induce receptivity for implantation.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Embryo Transfer</subject><subject>endometrium</subject><subject>epithelium</subject><subject>Epithelium - ultrastructure</subject><subject>Female</subject><subject>Freeze Fracturing</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Intercellular Junctions - ultrastructure</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>oocyte donation</subject><subject>Sterility. 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Assisted procreation</topic><topic>tight junction</topic><topic>Turner Syndrome - pathology</topic><topic>Turner's syndrome</topic><topic>Uterus - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rogers, P. A. W.</creatorcontrib><creatorcontrib>Murphy, C. R.</creatorcontrib><creatorcontrib>Leeton, J.</creatorcontrib><creatorcontrib>Hosie, M. J.</creatorcontrib><creatorcontrib>Beaton, L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rogers, P. A. 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Two patients subsequently became pregnant following embryo transfer. It is concluded that compromised epithelial integrity does not prevent embryo implantation in the human, an observation that is consistent with a barrier role for the epithelium except at times when appropriately conditioned with oestrogen and progesterone to induce receptivity for implantation.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>1500490</pmid><doi>10.1093/oxfordjournals.humrep.a137754</doi><tpages>3</tpages></addata></record>
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source	Oxford University Press Archive
subjects	Adult Biological and medical sciences Birth control Embryo Transfer endometrium epithelium Epithelium - ultrastructure Female Freeze Fracturing Gynecology. Andrology. Obstetrics Humans Intercellular Junctions - ultrastructure Medical sciences Microscopy, Electron oocyte donation Sterility. Assisted procreation tight junction Turner Syndrome - pathology Turner's syndrome Uterus - ultrastructure
title	Turner's syndrome patients lack tight junctions between uterine epithelial cells
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