Distribution of human CD30 gene promoter microsatellite alleles in healthy and human immunodeficiency virus-1 infected populations

Summary The human CD30 gene, found on chromosome 1; 1p36, contains a microsatellite of the type [(CCAT)2−12CCACTTATGCAT]n within the promoter. As the microsatellite has been shown to be both polymorphic and involved in the transcriptional regulation of this gene, it is of potential interest with res...

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Bibliographic Details
Published in:European journal of immunogenetics 2003-04, Vol.30 (2), p.125-128
Main Authors: McIntyre, M. Q., Price, P., Franchina, M., French, M. A., Abraham, L. J.
Format: Article
Language:English
Subjects:
HIV Infections - genetics
HIV-1 - genetics
Humans
Ki-1 Antigen - genetics
Microsatellite Repeats
Promoter Regions, Genetic
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Summary:Summary The human CD30 gene, found on chromosome 1; 1p36, contains a microsatellite of the type [(CCAT)2−12CCACTTATGCAT]n within the promoter. As the microsatellite has been shown to be both polymorphic and involved in the transcriptional regulation of this gene, it is of potential interest with respect to interindividual differences in CD30 expression. Here we describe a method for determining length variation of this repeat region and determine the frequency and distribution of alleles of the CD30 microsatellite within the Western Australian population. As soluble CD30 levels are predictive for disease associated with human immunodeficiency virus (HIV)‐1 infection, we also determined allele frequencies in an HIV+ cohort.
ISSN:0960-7420
1365-2370
DOI:10.1046/j.1365-2370.2003.00371.x