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Neurofilaments and neurological disease

Neurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by post‐translational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells. Neurofilament accum...

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Published in:	BioEssays 2003-04, Vol.25 (4), p.346-355
Main Authors:	Al-Chalabi, Ammar, Miller, Christopher C. J.
Format:	Article
Language:	English
Subjects:	Animals Biological Transport - physiology Humans Intermediate Filaments - metabolism Intermediate Filaments - ultrastructure Mice Mice, Transgenic Mutation Nervous System Diseases - genetics Nervous System Diseases - metabolism Nervous System Diseases - pathology Neurofilament Proteins - chemistry Neurofilament Proteins - genetics Neurofilament Proteins - metabolism Neurons - metabolism Neurons - ultrastructure Protein Subunits - metabolism Spinal Cord - metabolism Spinal Cord - pathology Superoxide Dismutase - genetics Superoxide Dismutase-1 tau Proteins - genetics
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description	Neurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by post‐translational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells. Neurofilament accumulations are seen in several neurological diseases and neurofilament mutations have now been associated with Charcot‐Marie‐Tooth disease, Parkinson's disease and amyotrophic lateral sclerosis. In this review, we discuss the structure, normal function and molecular pathology of neurofilaments. BioEssays 25:346–355, 2003. © 2003 Wiley Periodicals, Inc.
doi_str_mv	10.1002/bies.10251
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subjects	Animals Biological Transport - physiology Humans Intermediate Filaments - metabolism Intermediate Filaments - ultrastructure Mice Mice, Transgenic Mutation Nervous System Diseases - genetics Nervous System Diseases - metabolism Nervous System Diseases - pathology Neurofilament Proteins - chemistry Neurofilament Proteins - genetics Neurofilament Proteins - metabolism Neurons - metabolism Neurons - ultrastructure Protein Subunits - metabolism Spinal Cord - metabolism Spinal Cord - pathology Superoxide Dismutase - genetics Superoxide Dismutase-1 tau Proteins - genetics
title	Neurofilaments and neurological disease
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