Double-stranded RNA-binding proteins could suppress RNA interference-mediated antiviral defences

Agricultural Biotechnology Center, Plant Biology Institute, P.O. Box 411, H-2101, Gödöll , Hungary Correspondence Dániel Silhavy silhavy{at}abc.hu RNA interference (RNAi) is a double-stranded (ds)RNA-inducible, sequence-specific RNA-degradation mechanism that operates as a natural antiviral system i...

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Published in:Journal of general virology 2003-04, Vol.84 (4), p.975-980
Main Authors: Lichner, Zsuzsanna, Silhavy, Daniel, Burgyan, Jozsef
Format: Article
Language:English
Subjects:
Plant Proteins - metabolism
Plant Proteins - pharmacology
Plant Viruses - genetics
Plant Viruses - pathogenicity
RNA Interference
RNA Viruses - genetics
RNA Viruses - pathogenicity
RNA, Viral - antagonists & inhibitors
RNA, Viral - metabolism
RNA-Binding Proteins - metabolism
RNA-Binding Proteins - pharmacology
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creator Lichner, Zsuzsanna
Silhavy, Daniel
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description Agricultural Biotechnology Center, Plant Biology Institute, P.O. Box 411, H-2101, Gödöll , Hungary Correspondence Dániel Silhavy silhavy{at}abc.hu RNA interference (RNAi) is a double-stranded (ds)RNA-inducible, sequence-specific RNA-degradation mechanism that operates as a natural antiviral system in plants and animals. Successful virus infection requires evasion or suppression of RNAi. Indeed, RNAi suppressor proteins have been identified in plant and animal viruses, although the molecular mechanism of silencing inhibition is still poorly understood. Because many RNA viruses encode dsRNA-binding proteins (dsRBPs) and as RNAi is triggered by the accumulation of dsRNAs, dsRBPs were examined to see if they inhibit RNAi. Here, it is shown that heterologous dsRBPs suppressed RNAi in plants, indicating that in natural host–virus interactions, pathogen-encoded dsRBPs could inactivate RNAi-mediated host defences. Published ahead of print on 22 January 2003 as DOI 10.1099/vir.0.18987-0.
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subjects Plant Proteins - metabolism
Plant Proteins - pharmacology
Plant Viruses - genetics
Plant Viruses - pathogenicity
RNA Interference
RNA Viruses - genetics
RNA Viruses - pathogenicity
RNA, Viral - antagonists & inhibitors
RNA, Viral - metabolism
RNA-Binding Proteins - metabolism
RNA-Binding Proteins - pharmacology
title Double-stranded RNA-binding proteins could suppress RNA interference-mediated antiviral defences
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