Comparison of red blood cell volume distribution curves and phase-contrast microscopy in localization of the origin of hematuria

To determine the ability, reliability, and accuracy of urinary red blood cell volume distribution curves obtained with the use of an autoanalyzer to identify the origin of isolated microscopic hematuria and compare the results with those obtained with phase-contrast microscopy (PCM). A prospective e...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2003-03, Vol.61 (3), p.507-511
Main Authors: Gamé, Xavier, Soulié, Michel, Fontanilles, Anne-Marie, Benoit, Jean-Michel, Corberand, J.ol-Xavier, Plante, Pierre
Format: Article
Language:English
Subjects:
Adult
Aged
Autoanalysis - methods
Biological and medical sciences
Diagnosis, Differential
Erythrocyte Volume
Erythrocytes - cytology
Female
Hematuria - diagnosis
Hematuria - urine
Humans
Kidney Diseases - diagnosis
Kidney Diseases - pathology
Kidney Glomerulus - pathology
Male
Medical sciences
Microscopy, Phase-Contrast - methods
Middle Aged
Nephrology. Urinary tract diseases
Prospective Studies
Reproducibility of Results
Urinalysis - methods
Urinary system involvement in other diseases. Miscellaneous
Urinary tract. Prostate gland
Urine - cytology
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Summary:To determine the ability, reliability, and accuracy of urinary red blood cell volume distribution curves obtained with the use of an autoanalyzer to identify the origin of isolated microscopic hematuria and compare the results with those obtained with phase-contrast microscopy (PCM). A prospective evaluation was performed in 45 patients with glomerular or nonglomerular microhematuria detected by urinalysis, PCM, radiologic evaluation, endoscopy, and, sometimes, renal biopsy. Urine samples were analyzed in an electronic particle-size analyzer, and the tests were repeated to assess reliability. The kappa correlation coefficient was used to assess reliability and to compare the results with the final diagnosis and with those obtained with PCM. Of the 28 patients who had a single definite cause of hematuria, 16 had glomerular bleeding and 12 nonglomerular bleeding. The origin of hematuria was correctly identified by the autoanalyzer in 60.7% of cases. A statistically significant correlation was found with the final diagnosis (kappa = 0.433, P = 0.048). The reliability was excellent (kappa = 0.917, P
ISSN:0090-4295
1527-9995
DOI:10.1016/S0090-4295(02)02251-3