The prevalence of coronary artery calcium Among diabetic individuals without known coronary artery disease

We sought to examine the age and gender distribution of coronary artery calcium (CAC) by diabetes status in a large cohort of asymptomatic individuals. Among individuals with diabetes, coronary artery disease (CAD) is a major cause of morbidity and mortality. Electron-beam tomography (EBT) quantifie...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2003-03, Vol.41 (6), p.1008-1012
Main Authors: HOFF, Julie Anne, QUINN, Lauretta, SEVRUKOV, Alexander, LIPTON, Rebecca B, DAVIGLUS, Martha, GARSIDE, Daniel B, AJMERE, Niraj K, GANDHI, Sanjay, KONDOS, George T
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Associated diseases and complications
Biological and medical sciences
Calcinosis - diagnostic imaging
Calcinosis - epidemiology
Calcinosis - etiology
Cohort Studies
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary Artery Disease - etiology
Diabetes Complications
Diabetes Mellitus - diagnostic imaging
Diabetes Mellitus - epidemiology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Humans
Male
Medical sciences
Middle Aged
Prevalence
Risk Factors
Sex Factors
Tomography, X-Ray Computed
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Summary:We sought to examine the age and gender distribution of coronary artery calcium (CAC) by diabetes status in a large cohort of asymptomatic individuals. Among individuals with diabetes, coronary artery disease (CAD) is a major cause of morbidity and mortality. Electron-beam tomography (EBT) quantifies CAC, a marker for atherosclerosis. Screening for CAC by EBT was performed in 30,904 asymptomatic individuals stratified by their self-reported diabetes status, gender, and age. The distribution of CAC across the strata and the association between diabetes and CAC were examined. Compared with nondiabetic individuals (n = 29,829), those with diabetes (n = 1,075) had higher median CAC scores across all but two age groups (women 40 to 44 years old and men and women > or =70 years old). Overall, the likelihood of having a CAC score in the highest age/gender quartile was 70% greater for diabetic individuals than for their nondiabetic counterparts. Younger diabetic individuals appear to have calcified plaque burden comparable to that of older individuals without diabetes. These findings call for future research to determine if EBT-CAC screening has an incremental value over the current CAD risk assessment of individuals with diabetes.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(02)02975-3