Testicular cancer and Hodgkin’s disease: evaluation of semen quality

BACKGROUND: The aim of our study was to establish whether there is a difference in semen quality between patients with testicular cancer (TC) and Hodgkin’s disease (HD). METHODS: We evaluated 342 patients affected by TC (n = 232) or HD (n = 110) who cryobanked sperm before initiating chemo‐ or radio...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2003-04, Vol.18 (4), p.796-801
Main Authors: Gandini, Loredana, Lombardo, Francesco, Salacone, Pietro, Paoli, Donatella, Anselmo, Anna Paola, Culasso, Franco, Dondero, Franco, Lenzi, Andrea
Format: Article
Language:English
Subjects:
Acrosome Reaction
Adult
Biological and medical sciences
Blood Sedimentation
Chorionic Gonadotropin, beta Subunit, Human - blood
Cryopreservation
Gynecology. Andrology. Obstetrics
Hodgkin Disease - complications
Hodgkin Disease - drug therapy
Hodgkin Disease - physiopathology
Hodgkin Disease - radiotherapy
Humans
Key words: Hodgkin’s disease/semen quality/testicular cancer
Male
Male genital diseases
Medical sciences
Neoplasm Staging
Oligospermia - etiology
Oligospermia - pathology
Oligospermia - physiopathology
Orchiectomy
Postoperative Period
Semen
Sperm Count
Sperm Motility
Sperm-Ovum Interactions
Spermatogenesis
Spermatozoa - abnormalities
Testicular Neoplasms - complications
Testicular Neoplasms - pathology
Testicular Neoplasms - physiopathology
Testicular Neoplasms - surgery
Tumors
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Summary:BACKGROUND: The aim of our study was to establish whether there is a difference in semen quality between patients with testicular cancer (TC) and Hodgkin’s disease (HD). METHODS: We evaluated 342 patients affected by TC (n = 232) or HD (n = 110) who cryobanked sperm before initiating chemo‐ or radiotherapy. All TC patients were evaluated ∼1 month after orchidectomy. RESULTS: A total of 14 patients were azoospermic or cryptozoospermic. In the TC group (n = 222) the mean of the semen parameters was normal according to the World Health Organization (1992). However, dividing the cases into total sperm count ≥40×106/ejaculate and 5 mIU/ml) and those with normal serum βhCG. Comparison of semen parameters between TC stages I and II showed no significant differences. In the HD group (n = 106), we found that by and large they showed normal spermatogenesis, with only 24.5% having a total sperm count
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/deg163