Role of nitric oxide in the pathophysiology of heart failure

Nitric oxide (NO) plays critical roles in the regulation of integrated cardiac and vascular function and homeostasis. An understanding of the physiologic role and relative contribution of the three NO synthase isoforms (neuronal--NOS1, inducible--NOS2, and endothelial--NOS3) is imperative to compreh...

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Bibliographic Details
Published in:Heart failure reviews 2003-01, Vol.8 (1), p.35-46
Main Authors: Champion, Hunter C, Skaf, Michel W, Hare, Joshua M
Format: Article
Language:English
Subjects:
Endothelium, Vascular - cytology
Endothelium, Vascular - metabolism
Endothelium, Vascular - physiopathology
Heart Failure - physiopathology
Humans
Myocytes, Cardiac - metabolism
Nitric Oxide - physiology
Signal Transduction - physiology
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Summary:Nitric oxide (NO) plays critical roles in the regulation of integrated cardiac and vascular function and homeostasis. An understanding of the physiologic role and relative contribution of the three NO synthase isoforms (neuronal--NOS1, inducible--NOS2, and endothelial--NOS3) is imperative to comprehend derangements of the NO signaling pathway in the failing cardiovascular system. Several theories of NO and its regulation have developed as explanations for the divergent observations from studies in health and disease states. Here we review the physiologic and pathophysiologic influence of NO on cardiac function, in a framework that considers several theories of altered NO signaling in heart failure. We discuss the notion of spatial compartmentalization of NO signaling within the myocyte in an effort to reconcile many controversies about derangements in the influences of NO in the heart and vasculature.
ISSN:1382-4147
1573-7322
DOI:10.1023/A:1022142904202