Notch signalling in the regulation of peripheral T-cell function

The Notch signalling pathway plays a highly-conserved role in regulating the cellular differentiation and proliferation events that characterise pattern formation in the embryo. As cells in the embryo respond to environmental signals, similarly T-cells in the peripheral immune system must monitor th...

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Bibliographic Details
Published in:Seminars in cell & developmental biology 2003-04, Vol.14 (2), p.127-134
Main Authors: Mckenzie, Grahame J., Young, Lesley L., Briend, Emmanuel, Lamb, Jonathan R., Dallman, Margaret J., Champion, Brian R.
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - immunology
Cell fate
Immune Tolerance - immunology
Ligands
Membrane Proteins - genetics
Membrane Proteins - metabolism
Models, Biological
Notch
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
Receptors, Notch
Signal Transduction - physiology
T-cell
T-Lymphocytes - cytology
T-Lymphocytes - immunology
Tolerance
Treg
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Summary:The Notch signalling pathway plays a highly-conserved role in regulating the cellular differentiation and proliferation events that characterise pattern formation in the embryo. As cells in the embryo respond to environmental signals, similarly T-cells in the peripheral immune system must monitor their environment for antigens and respond accordingly by entering one of several potential differentiation pathways. Recent studies have identified a role for the Notch pathway in regulating the responses of T-cells in the periphery. In this review, we discuss these findings in the context of the Notch signalling pathway’s role as an orchestrator of cellular differentiation, and propose a central role for Notch as a regulator of immune system function.
ISSN:1084-9521
1096-3634
DOI:10.1016/S1084-9521(02)00181-7