First enantiodivergent Baeyer–Villiger oxidation by recombinant whole-Cells expressing two monooxygenases from Brevibacterium

Microbial Baeyer–Villiger oxidations of representative mesomeric ketones with recombinant Escherichia coli cells expressing two monooxygenases from Brevibacterium were investigated. The two enzymes displayed enantiodivergent biotransformations on an array of structurally diverse substrates, allowing...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2003-04, Vol.13 (8), p.1479-1482
Main Authors: Mihovilovic, Marko D, Rudroff, Florian, Müller, Bernhard, Stanetty, Peter
Format: Article
Language:English
Subjects:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Biotransformation
Brevibacterium - enzymology
Escherichia coli - enzymology
Escherichia coli - genetics
Fundamental and applied biological sciences. Psychology
Isoenzymes - genetics
Isoenzymes - metabolism
Ketones - chemistry
Ketones - metabolism
Lactones - chemical synthesis
Lactones - metabolism
Methods. Procedures. Technologies
Mixed Function Oxygenases - chemistry
Mixed Function Oxygenases - genetics
Mixed Function Oxygenases - metabolism
Oxidation-Reduction
Recombinant Proteins - chemistry
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Stereoisomerism
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Summary:Microbial Baeyer–Villiger oxidations of representative mesomeric ketones with recombinant Escherichia coli cells expressing two monooxygenases from Brevibacterium were investigated. The two enzymes displayed enantiodivergent biotransformations on an array of structurally diverse substrates, allowing access to some key lactone intermediates in natural compound synthesis. Enantiodivergent Baeyer–Villiger oxidations of prochiral ketones with recombinant Escherichia coli cells expressing two monooxygenases from Brevibacterium are reported.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(03)00137-9