A severity score for complicated skin and soft tissue infections derived from phase III studies of linezolid

Severity scoring systems are useful for assessing patient risk and predicting prognosis. We developed a scoring system using data from a phase III study comparing antibiotics in hospitalized patients with complicated skin and soft tissue infections (study A), and used logistic regression analysis to...

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Bibliographic Details
Published in:The American journal of surgery 2003-04, Vol.185 (4), p.369-375
Main Authors: Wilson, Samuel Eric, Solomkin, Joseph S, Le, Vu, Cammarata, Sue K, Bruss, Jon B
Format: Article
Language:English
Subjects:
Acetamides - therapeutic use
Adult
Aged
Analysis
Anti-Infective Agents - therapeutic use
Antimicrobial agents
Bacterial proteins
Biological and medical sciences
Clinical Trials, Phase III as Topic
Cloxacillin - therapeutic use
Comorbidity
Female
Flucloxacillin
General pharmacology
Health care
Heart attacks
Humans
Illnesses
Infections
Intensive care
Linezolid
Male
Medical sciences
Middle Aged
Mortality
Outcome Assessment (Health Care)
Oxacillin
Oxazolidinones - therapeutic use
Penicillins - therapeutic use
Pharmacology. Drug treatments
Prognosis
Protein synthesis
Risk
Scoring system
Severity of illness
Severity of Illness Index
Skin Diseases, Bacterial - diagnosis
Skin Diseases, Bacterial - drug therapy
Skin infection
Soft tissue infection
Soft Tissue Infections - drug therapy
Streptococcus infections
Treatment Failure
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Summary:Severity scoring systems are useful for assessing patient risk and predicting prognosis. We developed a scoring system using data from a phase III study comparing antibiotics in hospitalized patients with complicated skin and soft tissue infections (study A), and used logistic regression analysis to identify factors contributing to treatment failure. We tested this system using data from a similar study (study B). In study A (n = 682), cure rates were lower in patients with at least 1 comorbid condition ( P
ISSN:0002-9610
1879-1883
DOI:10.1016/S0002-9610(02)01411-3