Constant K+/Na+ excretion ratio during peak diuresis after piretanide but insignificant K+ loss during 24 hours

The effect of piretanide on Na+ and K+ excretion and on renal haemodynamics has been studied in 14 subjects with a GFR (Inulin clearance) ranging from 140 to 2 ml.min-1. After a two day fluid and salt balance control period, oral piretanide 6 mg induced a natriuresis and kaliuresis, which was propor...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1992-07, Vol.43 (1), p.23-27
Main Authors: KNAUF, H, MUTSCHLER, E
Format: Article
Language:English
Subjects:
Adult
Aged
Antihypertensive agents
Biological and medical sciences
Cardiovascular system
Diuresis - drug effects
Diuretics - pharmacology
Female
Glomerular Filtration Rate - drug effects
Hemodynamics
Humans
Kidney - physiopathology
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - urine
Male
Medical sciences
Middle Aged
Natriuresis - drug effects
Pharmacology. Drug treatments
Potassium - urine
Sodium - urine
Sulfonamides - pharmacology
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Summary:The effect of piretanide on Na+ and K+ excretion and on renal haemodynamics has been studied in 14 subjects with a GFR (Inulin clearance) ranging from 140 to 2 ml.min-1. After a two day fluid and salt balance control period, oral piretanide 6 mg induced a natriuresis and kaliuresis, which was proportional to the GFR of the patients. The ratio of drug-induced K+ to Na+ excretion was always 0.13, independent of individual GFR. This was only true for the duration of the action of piretanide, tau, which was 6 h in subjects with normal GFR and 5 h in patients with impaired kidney function. Surprisingly, after tau, i.e. for 24 h after drug administration, less potassium was lost than in the pretreatment period. Neither the GFR nor the renal blood flow (PAH clearance) of the patients were affected by piretanide. In conclusion, piretanide given once a day was an effective natriuretic agent, even in end-stage renal disease, and it produced relatively little K(+)-loss when given once daily.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF02280749