Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women

Although several lines of evidence point to an atherogenic role of central fat mass (CFM), few data are available to address the specific role played by peripheral fat mass (PFM). This study was a cross-sectional analysis of 1356 women aged 60 to 85 years. Study variables were physical measures, CFM...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2003-04, Vol.107 (12), p.1626-1631
Main Authors: TANKO, Laszlo B, BAGGER, Yu Z, ALEXANDERSEN, Peter, LARSEN, Philip J, CHRISTIANSEN, Claus
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adipose Tissue - anatomy & histology
Adipose Tissue - diagnostic imaging
Aged
Aortic Diseases - complications
Aortic Diseases - diagnostic imaging
Aortic Diseases - epidemiology
Arteriosclerosis - diagnostic imaging
Arteriosclerosis - epidemiology
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Body Composition
Body Mass Index
Calcinosis - complications
Calcinosis - diagnostic imaging
Calcinosis - epidemiology
Cardiology. Vascular system
Cardiovascular Diseases - epidemiology
Coronary Disease - complications
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - complications
Female
Humans
Insulin Resistance
Medical sciences
Obesity - complications
Risk Factors
Smoking - adverse effects
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Summary:Although several lines of evidence point to an atherogenic role of central fat mass (CFM), few data are available to address the specific role played by peripheral fat mass (PFM). This study was a cross-sectional analysis of 1356 women aged 60 to 85 years. Study variables were physical measures, CFM and PFM measured by DEXA, aortic calcification (AC) graded on lateral radiographs, lipid and glucose metabolites, blood pressure, and information on lifestyle factors and coronary disease. Peripheral fat mass showed independent negative correlation with both atherogenic metabolic risk factors and AC (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000057974.74060.68