Conjunctival epithelial cells from patients with Sjögren's syndrome inappropriately express major histocompatibility complex molecules, La(SSB) antigen, and heat-shock proteins

The La(SSB) antigen has been detected within the cytoplasm and on the membrane of conjunctival cells (CC) from patients with Sjögren's syndrome, whereas it was weakly expressed in the nucleus of normal cells. The diseased CC were shown to overproduce major histocompatibility complex (MHC) class...

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Bibliographic Details
Published in:Journal of clinical immunology 1992-07, Vol.12 (4), p.259-265
Main Authors: Yannopoulos, D I, Roncin, S, Lamour, A, Pennec, Y L, Moutsopoulos, H M, Youinou, P
Format: Article
Language:English
Subjects:
Autoantigens - biosynthesis
Conjunctiva - immunology
Epithelium - immunology
Heat-Shock Proteins - biosynthesis
Histocompatibility Antigens Class I - biosynthesis
Histocompatibility Antigens Class II - biosynthesis
Humans
Immunoenzyme Techniques
Ribonucleoproteins
Sjogren's Syndrome - immunology
SS-B Antigen
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Summary:The La(SSB) antigen has been detected within the cytoplasm and on the membrane of conjunctival cells (CC) from patients with Sjögren's syndrome, whereas it was weakly expressed in the nucleus of normal cells. The diseased CC were shown to overproduce major histocompatibility complex (MHC) class I antigens and express MHC class II antigens. Anti-heat-shock protein monoclonal antibody bound to the cell membrane in patients but not in normal controls.
ISSN:0271-9142
DOI:10.1007/BF00918149