Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents

A series of arylthioureas ( 1), aromatic aldehyde thiosemicarbazones ( 2) and 5-aryl-2-furfuraldehyde thiosemicarbazones ( 3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles ( 4). The newly synthesi...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2003-03, Vol.38 (3), p.313-318
Main Authors: Holla, B.Shivarama, Malini, K.V., Rao, B.Sooryanarayana, Sarojini, B.K., Kumari, N.Suchetha
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Anti-inflammatory activity
Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antibacterial activity
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Arylaldehydethiosemicarbazone
Arylfurfuraldehyde thiosemicarbazone
Arylthiourea
Bacteria - drug effects
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Carrageenan
Dimethyl Sulfoxide
Edema - chemically induced
Edema - prevention & control
Granulation Tissue - drug effects
Ibuprofen - pharmacology
Indicators and Reagents
Magnetic Resonance Spectroscopy
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Rats
Spectrophotometry, Infrared
Spectroscopy, Fourier Transform Infrared
Thiazoles
Thiazoles - chemical synthesis
Thiazoles - pharmacology
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Summary:A series of arylthioureas ( 1), aromatic aldehyde thiosemicarbazones ( 2) and 5-aryl-2-furfuraldehyde thiosemicarbazones ( 3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles ( 4). The newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. These compounds were also screened for their antibacterial and anti-inflammatory activities. Two of the newly synthesized compounds showed anti-inflammatory activity comparable with that of Ibuprofen.
ISSN:0223-5234
1768-3254
DOI:10.1016/S0223-5234(02)01447-2