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Atherogenic profile in preeclampsia
Atherosis is accepted to underlie the pathogenesis of preeclampsia, therefore we aimed to determine malonyldialdehyde (MDA) levels as a marker of lipid peroxidation, and lipoprotein(a) (Lp(a)), apolipoprotein A-1 (Apo A-1) and apolipoprotein B (Apo B) levels as a marker of atherogenic profile in pre...
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Published in: | Archives of gynecology and obstetrics 2003-04, Vol.268 (1), p.45-47 |
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container_title | Archives of gynecology and obstetrics |
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creator | Var, Ahmet Kuşcu, N Kemal Koyuncu, Faik Uyanik, B Sami Onur, Ece Yildirim, Yasemin Oruç, Semra |
description | Atherosis is accepted to underlie the pathogenesis of preeclampsia, therefore we aimed to determine malonyldialdehyde (MDA) levels as a marker of lipid peroxidation, and lipoprotein(a) (Lp(a)), apolipoprotein A-1 (Apo A-1) and apolipoprotein B (Apo B) levels as a marker of atherogenic profile in preeclamptic and normal pregnant women. Twenty preeclamptic and 20 gestational-age matched normal pregnant patients were enrolled in the study, mean gestational ages for the preeclamptic and the control group were 33.9+/-1.4 and 35.5+/-0.7 weeks, respectively. Blood was withdrawn from the patients soon after diagnosis, and from the controls at their routine prenatal visits. MDA levels was significantly higher in preeclamptic patients (P=0.0003), but no difference was observed in Apo A-1 and Apo B and Lp(a) levels between the 2 groups. We consider that higher MDA was due to oxidative stress seen in preeclampsia, and similar Apo A-1 and Apo B and Lp(a) levels were due to lack of systemic atherosis. |
doi_str_mv | 10.1007/s00404-002-0317-4 |
format | article |
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Twenty preeclamptic and 20 gestational-age matched normal pregnant patients were enrolled in the study, mean gestational ages for the preeclamptic and the control group were 33.9+/-1.4 and 35.5+/-0.7 weeks, respectively. Blood was withdrawn from the patients soon after diagnosis, and from the controls at their routine prenatal visits. MDA levels was significantly higher in preeclamptic patients (P=0.0003), but no difference was observed in Apo A-1 and Apo B and Lp(a) levels between the 2 groups. We consider that higher MDA was due to oxidative stress seen in preeclampsia, and similar Apo A-1 and Apo B and Lp(a) levels were due to lack of systemic atherosis.</description><subject>Adult</subject><subject>Apolipoprotein A-I - blood</subject><subject>Apolipoproteins</subject><subject>Apolipoproteins B - blood</subject><subject>Arteriosclerosis - blood</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Lipoprotein(a) - blood</subject><subject>Malondialdehyde - blood</subject><subject>Pre-Eclampsia - blood</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpdkM1LAzEQxYMotlb_AC9SKHhbnUnSJHss4hcUvOg5JNlZ3bIfNeke_O9NaUHwNG_gvcfMj7FrhDsE0PcJQIIsAHgBAnUhT9gUpcibRjxlUyj3GpSesIuUNgDIjVHnbIJcaSH1csoWq90XxeGT-ibMt3Gom5bmTZ8lUWhdt02Nu2RntWsTXR3njH08Pb4_vBTrt-fXh9W6CFzCrpBkqDSuEkZwWAbNDSoyJXiHEoTnVZCcy7J2Nbiq9MJ76WUIwWmlUROKGbs99OY7vkdKO9s1KVDbup6GMVktUKr8QjYu_hk3wxj7fJvlXKExGcYyu_DgCnFIKVJtt7HpXPyxCHbPzx742czP7vlZmTM3x-bRd1T9JY7AxC_2TWjF</recordid><startdate>200304</startdate><enddate>200304</enddate><creator>Var, Ahmet</creator><creator>Kuşcu, N Kemal</creator><creator>Koyuncu, Faik</creator><creator>Uyanik, B Sami</creator><creator>Onur, Ece</creator><creator>Yildirim, Yasemin</creator><creator>Oruç, Semra</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200304</creationdate><title>Atherogenic profile in preeclampsia</title><author>Var, Ahmet ; 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subjects | Adult Apolipoprotein A-I - blood Apolipoproteins Apolipoproteins B - blood Arteriosclerosis - blood Case-Control Studies Female Humans Lipoprotein(a) - blood Malondialdehyde - blood Pre-Eclampsia - blood Preeclampsia Pregnancy |
title | Atherogenic profile in preeclampsia |
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