Regulation of biosynthesis of vermiculin and vermistatin in Penicillium vermiculatum

Biosynthesis of vermiculin (1) and vermistatin (2) in Penicillium vermiculatum can be controlled by the carbon and nitrogen sources. Glucose and sucrose affect the levels of the two metabolites; cornsteep liquor influences the quality the biosynthesis. The concentrations of Fe3+ and Cu2+ ions also a...

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Bibliographic Details
Published in:Folia microbiologica 1992, Vol.37 (1), p.50-52
Main Authors: ADAMCOVA, J, PROKSA, B, FUSKA, J
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - biosynthesis
Biological and medical sciences
Carbon - physiology
Copper - physiology
Culture Media
Fundamental and applied biological sciences. Psychology
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Iron - physiology
Lactates - metabolism
Lactic Acid
Lactones - metabolism
Microbiology
Mycology
Nitrogen - physiology
Penicillium - metabolism
Pyrones - metabolism
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Summary:Biosynthesis of vermiculin (1) and vermistatin (2) in Penicillium vermiculatum can be controlled by the carbon and nitrogen sources. Glucose and sucrose affect the levels of the two metabolites; cornsteep liquor influences the quality the biosynthesis. The concentrations of Fe3+ and Cu2+ ions also affect the biosynthesis, the effect being dependent on the type of carbon source utilized. The compounds capable of electron transport generally stimulate the production of 1 and 2 but do not influence the biosynthesis qualitatively.
ISSN:0015-5632
1874-9356
DOI:10.1007/BF02814580