Treatment of persistent epithelial defects in neurotrophic keratitis with epidermal growth factor : a preliminary open study

We report three patients with persistent epithelial defects in the context of neurotrophic keratopathy that healed while on treatment with topically applied, mouse-derived epidermal growth factor (m-EGF). The clinical course of these patients was striking and suggests that EGF may have a potential r...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 1992, Vol.230 (4), p.314-317
Main Authors: DANIELE, S, GILBARD, J. P, SCHEPENS, C. L
Format: Article
Language:English
Subjects:
Administration, Topical
Adolescent
Adult
Biological and medical sciences
Cornea - innervation
Epidermal Growth Factor - administration & dosage
Epidermal Growth Factor - therapeutic use
Epithelium - drug effects
Eye
Fluorophotometry
Humans
Keratitis - therapy
Male
Medical sciences
Nervous System Diseases - drug therapy
Pharmacology. Drug treatments
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Summary:We report three patients with persistent epithelial defects in the context of neurotrophic keratopathy that healed while on treatment with topically applied, mouse-derived epidermal growth factor (m-EGF). The clinical course of these patients was striking and suggests that EGF may have a potential role in the treatment of persistent epithelial defects in subjects suffering from neurotrophic keratitis.
ISSN:0721-832X
1435-702X
DOI:10.1007/BF00165937