Methotrexate in the management of granulomatous mastitis

Granulomatous mastitis is a rare benign inflammatory breast disease that often clinically simulates carcinoma. Surgical resection of the entire lesion has been the main method of treatment but recurrence, infection, sinus formation and delayed wound healing can occur relatively commonly. Corticoster...

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Bibliographic Details
Published in:ANZ journal of surgery 2003-04, Vol.73 (4), p.247-249
Main Authors: Kim, Joon, Tymms, Kathleen E., Buckingham, John M.
Format: Article
Language:English
Subjects:
Adult
breast
corticosteroid
Female
granuloma
Granulomatous Disease, Chronic - complications
Granulomatous Disease, Chronic - drug therapy
Humans
hyperprolactinaemia
Immunosuppressive Agents - therapeutic use
mastitis
Mastitis - drug therapy
Mastitis - etiology
methotrexate
Methotrexate - therapeutic use
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Summary:Granulomatous mastitis is a rare benign inflammatory breast disease that often clinically simulates carcinoma. Surgical resection of the entire lesion has been the main method of treatment but recurrence, infection, sinus formation and delayed wound healing can occur relatively commonly. Corticosteroids are also effective in recurrent or resistant cases but are associated with side‐effects and relapse of disease after steroid withdrawal. A low weekly oral dose of methotrexate was used in five resistant cases after surgery plus corticosteroid. All cases achieved remission, withdrawal of corticosteroid without relapse and no methotrexate side‐effect.
ISSN:1445-1433
1445-2197
DOI:10.1046/j.1445-1433.2002.02564.x