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Pyridoacridine Alkaloids Inducing Neuronal Differentiation in a Neuroblastoma Cell Line, from Marine Sponge Biemna fortis
A new and three known pyridoacridine alkaloids were isolated from the Indonesian marine sponge Biemna fortis as neuronal differentiation inducers against a murine neuroblastoma cell line, Neuro 2A. The chemical structure of the new compound, labuanine A ( 1), was determined by spectroscopic study an...
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| Published in: | Bioorganic & medicinal chemistry 2003-05, Vol.11 (9), p.1969-1973 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c457t-74b550d2363244f4708bdc0dec7ec5aba948635f8fdc909004b0ebf6bc59ad83 |
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| cites | cdi_FETCH-LOGICAL-c457t-74b550d2363244f4708bdc0dec7ec5aba948635f8fdc909004b0ebf6bc59ad83 |
| container_end_page | 1973 |
| container_issue | 9 |
| container_start_page | 1969 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 11 |
| creator | Aoki, Shunji Wei, Hong Matsui, Kouhei Rachmat, Rachmaniar Kobayashi, Motomasa |
| description | A new and three known pyridoacridine alkaloids were isolated from the Indonesian marine sponge
Biemna fortis as neuronal differentiation inducers against a murine neuroblastoma cell line, Neuro 2A. The chemical structure of the new compound, labuanine A (
1), was determined by spectroscopic study and chemical conversion. These pyridoacridine alkaloids induced multipolar neuritogenesis in more than 50% of cells at 0.03–3 μM concentration. Compound
3, which showed the strongest neuritogenic activity among them, also induced increase of acetylcholinesterase, a neuronal marker in Neuro 2A and arrested cell cycle at the G2/M phase.
Labuanine A (
1), a novel pyridoacridine alkaloid and three known related compounds
2–
4 were isolated from marine sponge
Bienna fortis as neuronal differentiation inducers against a murine neuroblastoma cell line, Neuro 2A. |
| doi_str_mv | 10.1016/S0968-0896(03)00086-5 |
| format | article |
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Biemna fortis as neuronal differentiation inducers against a murine neuroblastoma cell line, Neuro 2A. The chemical structure of the new compound, labuanine A (
1), was determined by spectroscopic study and chemical conversion. These pyridoacridine alkaloids induced multipolar neuritogenesis in more than 50% of cells at 0.03–3 μM concentration. Compound
3, which showed the strongest neuritogenic activity among them, also induced increase of acetylcholinesterase, a neuronal marker in Neuro 2A and arrested cell cycle at the G2/M phase.
Labuanine A (
1), a novel pyridoacridine alkaloid and three known related compounds
2–
4 were isolated from marine sponge
Bienna fortis as neuronal differentiation inducers against a murine neuroblastoma cell line, Neuro 2A.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/S0968-0896(03)00086-5</identifier><identifier>PMID: 12670647</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acridines - chemistry ; Acridines - isolation & purification ; Acridines - pharmacology ; Alkaloids - chemistry ; Alkaloids - isolation & purification ; Alkaloids - pharmacology ; Animals ; Biological and medical sciences ; Cell Differentiation - drug effects ; Cell Differentiation - physiology ; Cell Line, Tumor - cytology ; Cell Line, Tumor - drug effects ; Cell Transformation, Neoplastic - drug effects ; Cell Transformation, Neoplastic - pathology ; General pharmacology ; Medical sciences ; Mice ; Neuroblastoma ; Neurons - cytology ; Neurons - drug effects ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phenanthrolines - chemistry ; Phenanthrolines - isolation & purification ; Phenanthrolines - pharmacology ; Porifera</subject><ispartof>Bioorganic & medicinal chemistry, 2003-05, Vol.11 (9), p.1969-1973</ispartof><rights>2003 Elsevier Science Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-74b550d2363244f4708bdc0dec7ec5aba948635f8fdc909004b0ebf6bc59ad83</citedby><cites>FETCH-LOGICAL-c457t-74b550d2363244f4708bdc0dec7ec5aba948635f8fdc909004b0ebf6bc59ad83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14643480$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12670647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aoki, Shunji</creatorcontrib><creatorcontrib>Wei, Hong</creatorcontrib><creatorcontrib>Matsui, Kouhei</creatorcontrib><creatorcontrib>Rachmat, Rachmaniar</creatorcontrib><creatorcontrib>Kobayashi, Motomasa</creatorcontrib><title>Pyridoacridine Alkaloids Inducing Neuronal Differentiation in a Neuroblastoma Cell Line, from Marine Sponge Biemna fortis</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>A new and three known pyridoacridine alkaloids were isolated from the Indonesian marine sponge
Biemna fortis as neuronal differentiation inducers against a murine neuroblastoma cell line, Neuro 2A. The chemical structure of the new compound, labuanine A (
1), was determined by spectroscopic study and chemical conversion. These pyridoacridine alkaloids induced multipolar neuritogenesis in more than 50% of cells at 0.03–3 μM concentration. Compound
3, which showed the strongest neuritogenic activity among them, also induced increase of acetylcholinesterase, a neuronal marker in Neuro 2A and arrested cell cycle at the G2/M phase.
Labuanine A (
1), a novel pyridoacridine alkaloid and three known related compounds
2–
4 were isolated from marine sponge
Bienna fortis as neuronal differentiation inducers against a murine neuroblastoma cell line, Neuro 2A.</description><subject>Acridines - chemistry</subject><subject>Acridines - isolation & purification</subject><subject>Acridines - pharmacology</subject><subject>Alkaloids - chemistry</subject><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Line, Tumor - cytology</subject><subject>Cell Line, Tumor - drug effects</subject><subject>Cell Transformation, Neoplastic - drug effects</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neuroblastoma</subject><subject>Neurons - cytology</subject><subject>Neurons - drug effects</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenanthrolines - chemistry</subject><subject>Phenanthrolines - isolation & purification</subject><subject>Phenanthrolines - pharmacology</subject><subject>Porifera</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EokvhJ4B8AYFEYLz-SHJCZfmqtHxI7d1y7HFlSOzFTpD23-PtruiRi-fgZ94ZPUPIUwZvGDD19gp61TXQ9eol8FcA0KlG3iMrJpRoOO_ZfbL6h5yRR6X8rNBa9OwhOWNr1YIS7Yrsf-xzcMnY-oaI9GL8ZcYUXKGX0S02xBv6DZecohnph-A9ZoxzMHNIkYZIzfF3GE2Z02ToBseRbmvQa-pzmuhXkw-pV7sUb5C-DzhFQ33KcyiPyQNvxoJPTvWcXH_6eL350my_f77cXGwbK2Q7N60YpAS35oqvhfCihW5wFhzaFq00g-lFp7j0nXe2hx5ADICDV4OVvXEdPycvjrG7nH4vWGY9hWLrmiZiWopuOZOCK1lBeQRtTqVk9HqXw2TyXjPQB-X6Vrk--NTA9a1yfeh7dhqwDBO6u66T4wo8PwGmWDP6bKIN5Y6rB-Oig8q9O3JYbfwJmHWxAaNFFzLaWbsU_rPKX4aVn1s</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Aoki, Shunji</creator><creator>Wei, Hong</creator><creator>Matsui, Kouhei</creator><creator>Rachmat, Rachmaniar</creator><creator>Kobayashi, Motomasa</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Pyridoacridine Alkaloids Inducing Neuronal Differentiation in a Neuroblastoma Cell Line, from Marine Sponge Biemna fortis</title><author>Aoki, Shunji ; Wei, Hong ; Matsui, Kouhei ; Rachmat, Rachmaniar ; Kobayashi, Motomasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-74b550d2363244f4708bdc0dec7ec5aba948635f8fdc909004b0ebf6bc59ad83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acridines - chemistry</topic><topic>Acridines - isolation & purification</topic><topic>Acridines - pharmacology</topic><topic>Alkaloids - chemistry</topic><topic>Alkaloids - isolation & purification</topic><topic>Alkaloids - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Line, Tumor - cytology</topic><topic>Cell Line, Tumor - drug effects</topic><topic>Cell Transformation, Neoplastic - drug effects</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Neuroblastoma</topic><topic>Neurons - cytology</topic><topic>Neurons - drug effects</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenanthrolines - chemistry</topic><topic>Phenanthrolines - isolation & purification</topic><topic>Phenanthrolines - pharmacology</topic><topic>Porifera</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aoki, Shunji</creatorcontrib><creatorcontrib>Wei, Hong</creatorcontrib><creatorcontrib>Matsui, Kouhei</creatorcontrib><creatorcontrib>Rachmat, Rachmaniar</creatorcontrib><creatorcontrib>Kobayashi, Motomasa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aoki, Shunji</au><au>Wei, Hong</au><au>Matsui, Kouhei</au><au>Rachmat, Rachmaniar</au><au>Kobayashi, Motomasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pyridoacridine Alkaloids Inducing Neuronal Differentiation in a Neuroblastoma Cell Line, from Marine Sponge Biemna fortis</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>11</volume><issue>9</issue><spage>1969</spage><epage>1973</epage><pages>1969-1973</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>A new and three known pyridoacridine alkaloids were isolated from the Indonesian marine sponge
Biemna fortis as neuronal differentiation inducers against a murine neuroblastoma cell line, Neuro 2A. The chemical structure of the new compound, labuanine A (
1), was determined by spectroscopic study and chemical conversion. These pyridoacridine alkaloids induced multipolar neuritogenesis in more than 50% of cells at 0.03–3 μM concentration. Compound
3, which showed the strongest neuritogenic activity among them, also induced increase of acetylcholinesterase, a neuronal marker in Neuro 2A and arrested cell cycle at the G2/M phase.
Labuanine A (
1), a novel pyridoacridine alkaloid and three known related compounds
2–
4 were isolated from marine sponge
Bienna fortis as neuronal differentiation inducers against a murine neuroblastoma cell line, Neuro 2A.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12670647</pmid><doi>10.1016/S0968-0896(03)00086-5</doi><tpages>5</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry, 2003-05, Vol.11 (9), p.1969-1973 |
| issn | 0968-0896 1464-3391 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Acridines - chemistry Acridines - isolation & purification Acridines - pharmacology Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Biological and medical sciences Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line, Tumor - cytology Cell Line, Tumor - drug effects Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - pathology General pharmacology Medical sciences Mice Neuroblastoma Neurons - cytology Neurons - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenanthrolines - chemistry Phenanthrolines - isolation & purification Phenanthrolines - pharmacology Porifera |
| title | Pyridoacridine Alkaloids Inducing Neuronal Differentiation in a Neuroblastoma Cell Line, from Marine Sponge Biemna fortis |
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