Septal polydipsia in rats is a primary polydipsia not mediated by dopamine

Bilateral lesions of nucleus septal lateralis resulted in a sustained and significant increase in water intake, without any change in food intake. Intracerebral injection of dopamine (DA) or of spiperone (a central D2-receptor antagonist) did not elicit any change in water or food intake. The polydi...

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Bibliographic Details
Published in:Indian journal of physiology and pharmacology 1992-04, Vol.36 (2), p.101-104
Main Authors: Pal, G K, Thombre, D P
Format: Article
Language:English
Subjects:
Animals
Dopamine - pharmacology
Drinking - drug effects
Eating - drug effects
Male
Rats
Rats, Inbred Strains
Septal Nuclei - drug effects
Septal Nuclei - physiology
Spiperone - pharmacology
Thirst - physiology
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Summary:Bilateral lesions of nucleus septal lateralis resulted in a sustained and significant increase in water intake, without any change in food intake. Intracerebral injection of dopamine (DA) or of spiperone (a central D2-receptor antagonist) did not elicit any change in water or food intake. The polydipsia resulting from septal lesions is thus a primary polydipsia, which is independent of food intake, and is not mediated by neurotransmitter dopamine.
ISSN:0019-5499