1H- and 13C-nmr Assignments for Taxol, 7-epi-Taxol, and Cephalomannine

The 1H- and 13C-nmr spectra of taxol [1], 7-epi-taxol [2], and cephalomannine [3] were assigned using modern 1D and 2D nmr methods. Preliminary conformational information was obtained by nOe spectroscopy.

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1992-04, Vol.55 (4), p.414-423
Main Authors: Chmurny, Gwendolyn N, Hilton, Bruce D, Brobst, Susan, Look, Sally A, Witherup, Keith M, Beutler, John A
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
Alkaloids - chemistry
ANTINEOPLASTIC AGENTS
Antineoplastic Agents, Phytogenic - chemistry
Biological and medical sciences
DITERPENOIDE
DITERPENOIDS
DITERPENOS
ESPECTROSCOPIA RMN
General pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
MEDICAMENT CYTOSTATIQUE
MOLECULAR CONFORMATION
NMR SPECTROSCOPY
NUCLEAR MAGNETIC RESONANCE
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Paclitaxel
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
SPECTROSCOPIE RMN
STRUCTURE
Taxoids
TAXUS
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Description
Summary:The 1H- and 13C-nmr spectra of taxol [1], 7-epi-taxol [2], and cephalomannine [3] were assigned using modern 1D and 2D nmr methods. Preliminary conformational information was obtained by nOe spectroscopy.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50082a002