Involvement of brain endogenous cholecystokinin in stress-induced impairment of spatial recognition memory

The central fragment of cholecystokinin, CCK8, plays a critical role in stress-related changes in behavior and memory. Therefore, we investigated whether the endogenous cholecystokininergic system is involved in the impairment of attention and/or memory induced by stressful conditions. Plasma cortic...

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Bibliographic Details
Published in:Neuroscience 2003-04, Vol.118 (1), p.19-23
Main Authors: DAUGE, V, POPHILLAT, M, CRETE, D, MELIK-PARSADANIANTZ, S, ROQUES, B. P
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Animals
Behavioral psychophysiology
Biological and medical sciences
Brain - metabolism
Brain - physiopathology
Cholecystokinin - deficiency
Corticosterone - blood
Down-Regulation - physiology
Fundamental and applied biological sciences. Psychology
Hippocampus - metabolism
Hippocampus - physiopathology
Male
Maze Learning - physiology
Memory Disorders - metabolism
Memory Disorders - physiopathology
Neural Pathways - metabolism
Neural Pathways - physiopathology
Neurotransmission and behavior
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
Stress, Physiological - metabolism
Stress, Physiological - physiopathology
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Summary:The central fragment of cholecystokinin, CCK8, plays a critical role in stress-related changes in behavior and memory. Therefore, we investigated whether the endogenous cholecystokininergic system is involved in the impairment of attention and/or memory induced by stressful conditions. Plasma corticosterone concentrations increased three-fold and plasma adrenocorticotropin (ACTH); concentrations increased five-fold when rats were maintained in the open arm of an elevated plus maze for 5 min. The same stress conditions impaired spatial recognition in the two-trial memory task. In addition, this stress led to a significant decrease in the extracellular levels of cholecystokinin-like immunoreactivity in the dorsal subiculum/CA1 of the hippocampus and partially suppressed the increase obtained during the acquisition phase of memory. This suggests that the cholecystokininergic system in the hippocampus is involved in stress-induced impairment of spatial recognition memory.
ISSN:0306-4522
1873-7544
DOI:10.1016/S0306-4522(02)00932-6