Double-Blind Comparison of Captopril with Nifedipine in Hypertension Complicated by Intermittent Claudication

In a double-blind, crossover trial 12 patients with hypertension and peripheral arterial disease were randomized to three months' treatment with captopril 25-50 mg twice daily or nifedipine SR 20-40 mg twice daily. While both treatments were equally effective at lowering blood pressure, postexe...

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Bibliographic Details
Published in:Angiology 1992-09, Vol.43 (9), p.748-756
Main Authors: Roberts, David H., Tsao, Yvonne, Linge, Keith, McLoughlin, Gerard A., Breckenridge, Alasdair
Format: Article
Language:English
Subjects:
Antihypertensive agents
Biological and medical sciences
Blood Pressure - drug effects
Captopril - therapeutic use
Cardiovascular system
Double-Blind Method
Exercise Test
Female
Humans
Hypertension - complications
Hypertension - drug therapy
Intermittent Claudication - complications
Male
Medical sciences
Middle Aged
Nifedipine - therapeutic use
Pharmacology. Drug treatments
Regional Blood Flow - drug effects
Time Factors
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Summary:In a double-blind, crossover trial 12 patients with hypertension and peripheral arterial disease were randomized to three months' treatment with captopril 25-50 mg twice daily or nifedipine SR 20-40 mg twice daily. While both treatments were equally effective at lowering blood pressure, postexercise calf blood flow availability was greater during treatment with captopril (P < 0.04). This was not reflected in walking capacity assessed by treadmill exercise. The results sug gest that both captopril and nifedipine are appropriate antihypertensive agents in patients with peripheral arterial disease.
ISSN:0003-3197
1940-1574
DOI:10.1177/000331979204300905