Müller cell and neuronal remodeling in retinal detachment and reattachment and their potential consequences for visual recovery: a review and reconsideration of recent data

Recent evidence suggests that the adult mammalian retina is far more plastic than was previously thought. Retinal detachment induces changes beyond the degeneration of outer segments (OS). Changes in photoreceptor synapses, second- and even third-order neurons may all contribute to imperfect visual...

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Bibliographic Details
Published in:Vision research (Oxford) 2003-04, Vol.43 (8), p.887-897
Main Authors: Fisher, Steven K., Lewis, Geoffrey P.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Humans
Medical sciences
Müller’s glia
Neuroglia - physiology
Neuronal Plasticity
Neuronal remodeling
Ophthalmology
Photoreceptors
Prognosis
Retinal detachment
Retinal Detachment - physiopathology
Retinal Detachment - surgery
Retinal reattachment
Retinopathies
Rod Cell Outer Segment - physiology
Synaptic plasticity
Vision, Ocular
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Summary:Recent evidence suggests that the adult mammalian retina is far more plastic than was previously thought. Retinal detachment induces changes beyond the degeneration of outer segments (OS). Changes in photoreceptor synapses, second- and even third-order neurons may all contribute to imperfect visual recovery that can occur after successful reattachment. Changes that occur in Müller cells have obvious effects through subretinal fibrosis and proliferative vitreoretinopathy, but other unidentified effects seem likely as well. Reattachment of the retina induces its own set of responses aside from OS re-growth. Reattachment halts the growth of Müller cell processes into the subretinal space, but induces their growth on the vitreal surface. It also induces the outgrowth of rod axons into the inner retina.
ISSN:0042-6989
1878-5646
DOI:10.1016/S0042-6989(02)00680-6