The effects of long-term adrenalectomy on 5-HT1B receptors mRNA expression in cerebellum, striatum, frontal cortex and hippocampus of rats

• Published in: Neuroscience letters 2003-04, Vol.340 (2), p.131-134
• Main Authors: CHENNAOUI, M, DROGOU, C, GOMEZ-MERINO, D, GUEZENNEC, C. Y
• Format: Article
• Language: English
• Subjects: Adrenalectomy; Animals; Biological and medical sciences; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; Cerebellum - metabolism; Corpus Striatum - metabolism; Frontal Lobe - metabolism; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - physiology; Hippocampus - metabolism; Male; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin - biosynthesis; Receptors, Serotonin - genetics; Receptors, Serotonin - metabolism; RNA, Messenger - biosynthesis; Time; Vertebrates: nervous system and sense organs
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/S0304-3940(03)00106-X

The brain serotonin (5-HT) system and circulating corticosteroids are in close interaction and both implicated in the pathogenesis of affective disorders. We evaluated the effects of adrenalectomy (ADX) on 5-HT(1B) receptors mRNA expression in cerebellum, frontal cortex, striatum and hippocampus in rats, using the RNase protection assay technique. Eight weeks after bilateral adrenalectomy, 5-HT(1B) receptor mRNA levels were decreased in the cerebellum and in the frontal cortex. The expression of 5-HT(1B) receptors mRNA was unchanged in the hippocampus and in the striatum. This data indicates regional differences in the effects of long term adrenalectomy on the expression of 5-HT(1B) receptors.