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The effects of long-term adrenalectomy on 5-HT1B receptors mRNA expression in cerebellum, striatum, frontal cortex and hippocampus of rats
The brain serotonin (5-HT) system and circulating corticosteroids are in close interaction and both implicated in the pathogenesis of affective disorders. We evaluated the effects of adrenalectomy (ADX) on 5-HT(1B) receptors mRNA expression in cerebellum, frontal cortex, striatum and hippocampus in...
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| Published in: | Neuroscience letters 2003-04, Vol.340 (2), p.131-134 |
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| cites | cdi_FETCH-LOGICAL-c335t-ed748e9dbdfbd5f79ad7d7e1e17b3ca075b195934620e36f827e4626a5d300863 |
| container_end_page | 134 |
| container_issue | 2 |
| container_start_page | 131 |
| container_title | Neuroscience letters |
| container_volume | 340 |
| creator | CHENNAOUI, M DROGOU, C GOMEZ-MERINO, D GUEZENNEC, C. Y |
| description | The brain serotonin (5-HT) system and circulating corticosteroids are in close interaction and both implicated in the pathogenesis of affective disorders. We evaluated the effects of adrenalectomy (ADX) on 5-HT(1B) receptors mRNA expression in cerebellum, frontal cortex, striatum and hippocampus in rats, using the RNase protection assay technique. Eight weeks after bilateral adrenalectomy, 5-HT(1B) receptor mRNA levels were decreased in the cerebellum and in the frontal cortex. The expression of 5-HT(1B) receptors mRNA was unchanged in the hippocampus and in the striatum. This data indicates regional differences in the effects of long term adrenalectomy on the expression of 5-HT(1B) receptors. |
| doi_str_mv | 10.1016/S0304-3940(03)00106-X |
| format | article |
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This data indicates regional differences in the effects of long term adrenalectomy on the expression of 5-HT(1B) receptors.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(03)00106-X</identifier><identifier>PMID: 12668254</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier</publisher><subject>Adrenalectomy ; Animals ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Cerebellum - metabolism ; Corpus Striatum - metabolism ; Frontal Lobe - metabolism ; Fundamental and applied biological sciences. 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Y</creatorcontrib><title>The effects of long-term adrenalectomy on 5-HT1B receptors mRNA expression in cerebellum, striatum, frontal cortex and hippocampus of rats</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The brain serotonin (5-HT) system and circulating corticosteroids are in close interaction and both implicated in the pathogenesis of affective disorders. We evaluated the effects of adrenalectomy (ADX) on 5-HT(1B) receptors mRNA expression in cerebellum, frontal cortex, striatum and hippocampus in rats, using the RNase protection assay technique. Eight weeks after bilateral adrenalectomy, 5-HT(1B) receptor mRNA levels were decreased in the cerebellum and in the frontal cortex. The expression of 5-HT(1B) receptors mRNA was unchanged in the hippocampus and in the striatum. This data indicates regional differences in the effects of long term adrenalectomy on the expression of 5-HT(1B) receptors.</description><subject>Adrenalectomy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Cerebellum - metabolism</subject><subject>Corpus Striatum - metabolism</subject><subject>Frontal Lobe - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - physiology</subject><subject>Hippocampus - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, Serotonin, 5-HT1B</subject><subject>Receptors, Serotonin - biosynthesis</subject><subject>Receptors, Serotonin - genetics</subject><subject>Receptors, Serotonin - metabolism</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Time</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpFkdFKHTEQhoO06Kn1EZTctFjo1slmk-xeqrRVEAv1CN6FbDKpW3Y32yQL-gp96u45HurV_DDfzPzMT8gxgy8MmDy7Aw5VwZsKToF_AmAgi4c9smK1KgvVqPINWf1HDsi7lH4DgGCi2icHrJSyLkW1In_Xj0jRe7Q50eBpH8ZfRcY4UOMijqZfGmF4pmGkorhaswsa0eKUQ0x0-Hl7TvFpiphStwDdSC1GbLHv5-EzTTl2Jm-Uj2HMpqc2xIxP1IyOPnbTFKwZpnl7Npqc3pO33vQJj3b1kNx_-7q-vCpufny_vjy_KSznIhfoVFVj41rnWye8aoxTTiFDplpuDSjRskY0vJIlIJe-LhUuWhrhOEAt-SH5-LJ3iuHPjCnroUt2MW1GDHPSijPJpGoWULyANoaUIno9xW4w8Vkz0JsQ9DYEvfmwBq63IeiHZe5kd2BuB3SvU7uvL8CHHWCSNb2PZrRdeuU2dmVV8n9PqpEP</recordid><startdate>20030410</startdate><enddate>20030410</enddate><creator>CHENNAOUI, M</creator><creator>DROGOU, C</creator><creator>GOMEZ-MERINO, D</creator><creator>GUEZENNEC, C. 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Pathways and receptors</topic><topic>Cerebellum - metabolism</topic><topic>Corpus Striatum - metabolism</topic><topic>Frontal Lobe - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - physiology</topic><topic>Hippocampus - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor, Serotonin, 5-HT1B</topic><topic>Receptors, Serotonin - biosynthesis</topic><topic>Receptors, Serotonin - genetics</topic><topic>Receptors, Serotonin - metabolism</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Time</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHENNAOUI, M</creatorcontrib><creatorcontrib>DROGOU, C</creatorcontrib><creatorcontrib>GOMEZ-MERINO, D</creatorcontrib><creatorcontrib>GUEZENNEC, C. 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| ispartof | Neuroscience letters, 2003-04, Vol.340 (2), p.131-134 |
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| language | eng |
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| source | Elsevier |
| subjects | Adrenalectomy Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebellum - metabolism Corpus Striatum - metabolism Frontal Lobe - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Hippocampus - metabolism Male Rats Rats, Wistar Receptor, Serotonin, 5-HT1B Receptors, Serotonin - biosynthesis Receptors, Serotonin - genetics Receptors, Serotonin - metabolism RNA, Messenger - biosynthesis Time Vertebrates: nervous system and sense organs |
| title | The effects of long-term adrenalectomy on 5-HT1B receptors mRNA expression in cerebellum, striatum, frontal cortex and hippocampus of rats |
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