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WS009 A AND B, NEW ENDOTHELIN RECEPTOR ANTAGONISTS ISOLATED FROM Streptomyces sp. No. 89009: I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES
WS009 A and B novel endothelin receptor antagonists, have been isolated from the fermentation broth of Streptomyces sp. No. 89009. These antagonists were purified from the culture filtrate followed by Diaion SP-207, DEAE Toyopearl column chromatography and HPLC. WS009 A and B showed selective activi...
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| Published in: | Journal of antibiotics 1992/07/25, Vol.45(7), pp.1029-1040 |
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| Main Authors: | , , , , , , , , , |
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| Language: | English |
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| container_end_page | 1040 |
| container_issue | 7 |
| container_start_page | 1029 |
| container_title | Journal of antibiotics |
| container_volume | 45 |
| creator | MIYATA, SUSUMU OHHATA, NOBUTAKA MURAI, HIDETUGU MASUI, YUKO EZAKI, MASAMI TAKASE, SHIGEHIRO NISHIKAWA, MOTOAKI KIYOTO, SUMIO OKUHARA, MASAKUNI KOHSAKA, MASANOBU |
| description | WS009 A and B novel endothelin receptor antagonists, have been isolated from the fermentation broth of Streptomyces sp. No. 89009. These antagonists were purified from the culture filtrate followed by Diaion SP-207, DEAE Toyopearl column chromatography and HPLC. WS009 A and B showed selective activity in an endothelin receptor binding assay with IC50 of 5.8 × 10-6M and 6.7 × 10-7M, respectively. On the basis of spectroscopic and chemical evidence, the structures of WS009 A and B have been established as 1 and 3, and are highly hydroxylated benz[a]anthraquinone chromophores. |
| doi_str_mv | 10.7164/antibiotics.45.1029 |
| format | article |
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No. 89009: I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES</title><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - Open Access English articles</source><creator>MIYATA, SUSUMU ; OHHATA, NOBUTAKA ; MURAI, HIDETUGU ; MASUI, YUKO ; EZAKI, MASAMI ; TAKASE, SHIGEHIRO ; NISHIKAWA, MOTOAKI ; KIYOTO, SUMIO ; OKUHARA, MASAKUNI ; KOHSAKA, MASANOBU</creator><creatorcontrib>MIYATA, SUSUMU ; OHHATA, NOBUTAKA ; MURAI, HIDETUGU ; MASUI, YUKO ; EZAKI, MASAMI ; TAKASE, SHIGEHIRO ; NISHIKAWA, MOTOAKI ; KIYOTO, SUMIO ; OKUHARA, MASAKUNI ; KOHSAKA, MASANOBU</creatorcontrib><description>WS009 A and B novel endothelin receptor antagonists, have been isolated from the fermentation broth of Streptomyces sp. No. 89009. These antagonists were purified from the culture filtrate followed by Diaion SP-207, DEAE Toyopearl column chromatography and HPLC. WS009 A and B showed selective activity in an endothelin receptor binding assay with IC50 of 5.8 × 10-6M and 6.7 × 10-7M, respectively. On the basis of spectroscopic and chemical evidence, the structures of WS009 A and B have been established as 1 and 3, and are highly hydroxylated benz[a]anthraquinone chromophores.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.45.1029</identifier><identifier>PMID: 1325433</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Anthraquinones - chemistry ; Anthraquinones - classification ; Anthraquinones - isolation & purification ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Applied microbiology ; Biological and medical sciences ; Chemotherapic agents ; Endothelins - metabolism ; Fermentation ; Fundamental and applied biological sciences. Psychology ; Magnetic Resonance Spectroscopy ; Methods ; Microbiology ; Receptors, Cell Surface - antagonists & inhibitors ; Receptors, Endothelin ; Streptomyces ; Streptomyces - metabolism</subject><ispartof>The Journal of Antibiotics, 1992/07/25, Vol.45(7), pp.1029-1040</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4559-e05d315f8d43a4de53a5f0349a0b34deeb07ef731e912d3c0f9a189d260e63d73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5604816$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1325433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIYATA, SUSUMU</creatorcontrib><creatorcontrib>OHHATA, NOBUTAKA</creatorcontrib><creatorcontrib>MURAI, HIDETUGU</creatorcontrib><creatorcontrib>MASUI, YUKO</creatorcontrib><creatorcontrib>EZAKI, MASAMI</creatorcontrib><creatorcontrib>TAKASE, SHIGEHIRO</creatorcontrib><creatorcontrib>NISHIKAWA, MOTOAKI</creatorcontrib><creatorcontrib>KIYOTO, SUMIO</creatorcontrib><creatorcontrib>OKUHARA, MASAKUNI</creatorcontrib><creatorcontrib>KOHSAKA, MASANOBU</creatorcontrib><title>WS009 A AND B, NEW ENDOTHELIN RECEPTOR ANTAGONISTS ISOLATED FROM Streptomyces sp. No. 89009: I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>WS009 A and B novel endothelin receptor antagonists, have been isolated from the fermentation broth of Streptomyces sp. No. 89009. These antagonists were purified from the culture filtrate followed by Diaion SP-207, DEAE Toyopearl column chromatography and HPLC. WS009 A and B showed selective activity in an endothelin receptor binding assay with IC50 of 5.8 × 10-6M and 6.7 × 10-7M, respectively. On the basis of spectroscopic and chemical evidence, the structures of WS009 A and B have been established as 1 and 3, and are highly hydroxylated benz[a]anthraquinone chromophores.</description><subject>Anthraquinones - chemistry</subject><subject>Anthraquinones - classification</subject><subject>Anthraquinones - isolation & purification</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Chemotherapic agents</subject><subject>Endothelins - metabolism</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Methods</subject><subject>Microbiology</subject><subject>Receptors, Cell Surface - antagonists & inhibitors</subject><subject>Receptors, Endothelin</subject><subject>Streptomyces</subject><subject>Streptomyces - metabolism</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNqFUE1r2zAAFaOjzdL9glLQoew0u5Il2dLRS9w24Nkj9uihB6HI8ubixJnkHPrvp-CQ9TYQEuJ98gC4wShMcEzv1W7sNt0wdtqFlIUYReIDmGHOcYBpLC7ADKEIB5xH6Ap8cu4VIZKQhF-CS0wiRgmZgZfnCiEBU5gWS_jtKyyyZ5gVy7J-yvJVAdfZIvtRl2sP1-ljWayquoKrqszTOlvCh3X5HVajNftx2L5p46Dbh7AYQsiFd70GH1vVO_P59M7Bz4esXjwFefm4WqR5oCljIjCINQSzljeUKNoYRhRrEaFCoQ3xf7NBiWkTgo3AUUM0aoXCXDRRjExMmoTMwZfJd2-HPwfjRrntnDZ9r3ZmODjppbE__yf6UX1vv8sckImo7eCcNa3c226r7JvESB63l--2l5TJ4_ZedXuyP2y2pvmnmcb2-N0JV06rvrVqpzt3prEYUe6bzkE-0V7dqH6ZM66sT-vN-2gsYn6MT6br2OJM07-VlWZH_gKtoKMg</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>MIYATA, SUSUMU</creator><creator>OHHATA, NOBUTAKA</creator><creator>MURAI, HIDETUGU</creator><creator>MASUI, YUKO</creator><creator>EZAKI, MASAMI</creator><creator>TAKASE, SHIGEHIRO</creator><creator>NISHIKAWA, MOTOAKI</creator><creator>KIYOTO, SUMIO</creator><creator>OKUHARA, MASAKUNI</creator><creator>KOHSAKA, MASANOBU</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>WS009 A AND B, NEW ENDOTHELIN RECEPTOR ANTAGONISTS ISOLATED FROM Streptomyces sp. No. 89009</title><author>MIYATA, SUSUMU ; OHHATA, NOBUTAKA ; MURAI, HIDETUGU ; MASUI, YUKO ; EZAKI, MASAMI ; TAKASE, SHIGEHIRO ; NISHIKAWA, MOTOAKI ; KIYOTO, SUMIO ; OKUHARA, MASAKUNI ; KOHSAKA, MASANOBU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4559-e05d315f8d43a4de53a5f0349a0b34deeb07ef731e912d3c0f9a189d260e63d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Anthraquinones - chemistry</topic><topic>Anthraquinones - classification</topic><topic>Anthraquinones - isolation & purification</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Chemotherapic agents</topic><topic>Endothelins - metabolism</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Methods</topic><topic>Microbiology</topic><topic>Receptors, Cell Surface - antagonists & inhibitors</topic><topic>Receptors, Endothelin</topic><topic>Streptomyces</topic><topic>Streptomyces - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MIYATA, SUSUMU</creatorcontrib><creatorcontrib>OHHATA, NOBUTAKA</creatorcontrib><creatorcontrib>MURAI, HIDETUGU</creatorcontrib><creatorcontrib>MASUI, YUKO</creatorcontrib><creatorcontrib>EZAKI, MASAMI</creatorcontrib><creatorcontrib>TAKASE, SHIGEHIRO</creatorcontrib><creatorcontrib>NISHIKAWA, MOTOAKI</creatorcontrib><creatorcontrib>KIYOTO, SUMIO</creatorcontrib><creatorcontrib>OKUHARA, MASAKUNI</creatorcontrib><creatorcontrib>KOHSAKA, MASANOBU</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MIYATA, SUSUMU</au><au>OHHATA, NOBUTAKA</au><au>MURAI, HIDETUGU</au><au>MASUI, YUKO</au><au>EZAKI, MASAMI</au><au>TAKASE, SHIGEHIRO</au><au>NISHIKAWA, MOTOAKI</au><au>KIYOTO, SUMIO</au><au>OKUHARA, MASAKUNI</au><au>KOHSAKA, MASANOBU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>WS009 A AND B, NEW ENDOTHELIN RECEPTOR ANTAGONISTS ISOLATED FROM Streptomyces sp. No. 89009: I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1992</date><risdate>1992</risdate><volume>45</volume><issue>7</issue><spage>1029</spage><epage>1040</epage><pages>1029-1040</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>WS009 A and B novel endothelin receptor antagonists, have been isolated from the fermentation broth of Streptomyces sp. No. 89009. These antagonists were purified from the culture filtrate followed by Diaion SP-207, DEAE Toyopearl column chromatography and HPLC. WS009 A and B showed selective activity in an endothelin receptor binding assay with IC50 of 5.8 × 10-6M and 6.7 × 10-7M, respectively. 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| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1992/07/25, Vol.45(7), pp.1029-1040 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73163167 |
| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - Open Access English articles |
| subjects | Anthraquinones - chemistry Anthraquinones - classification Anthraquinones - isolation & purification Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chemotherapic agents Endothelins - metabolism Fermentation Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Methods Microbiology Receptors, Cell Surface - antagonists & inhibitors Receptors, Endothelin Streptomyces Streptomyces - metabolism |
| title | WS009 A AND B, NEW ENDOTHELIN RECEPTOR ANTAGONISTS ISOLATED FROM Streptomyces sp. No. 89009: I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES |
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