Comparison of relative renal function by renal scintigraphy and lateralized creatinine clearance in children with bilateral vesicoureteral reflux

To evaluate the relative renal function on preoperative and postoperative renal scintigraphy with lateralized creatinine clearance. Multiple factors affect renal blood flow and glomerular filtration that alter the relative renal function calculated by renal scintigraphy. The relative renal function...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2003-04, Vol.61 (4), p.816-818
Main Authors: Mindrup, Steven R, Cooper, Christopher S, Hodroff, Marc A, Hawtrey, Charles E
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Creatinine - pharmacokinetics
Creatinine - urine
Female
Glomerular Filtration Rate - physiology
Humans
Infant
Kidney - diagnostic imaging
Kidney Function Tests - methods
Male
Postoperative Care
Preoperative Care
Radioisotope Renography
Renal Circulation - physiology
Retrospective Studies
Succimer
Sugar Acids
Ureter - surgery
Urinary Catheterization
Vesico-Ureteral Reflux - diagnosis
Vesico-Ureteral Reflux - surgery
Vesico-Ureteral Reflux - urine
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Summary:To evaluate the relative renal function on preoperative and postoperative renal scintigraphy with lateralized creatinine clearance. Multiple factors affect renal blood flow and glomerular filtration that alter the relative renal function calculated by renal scintigraphy. The relative renal function according to renal scintigraphy in children with bilateral vesicoureteral reflux has not been compared with lateralized creatinine clearance. We retrospectively reviewed the charts of 45 children treated surgically for bilateral vesicoureteral reflux. The average age at time of reimplantation was 5.3 years. Bilateral ureteral catheters were placed intraoperatively. Lateralized creatinine clearance was measured with 24-hour urine collections postoperatively from each catheter. Bladder catheterization was not performed during the renal scans. Thirty-six of 45 children had preoperative 1 to 3-minute relative renal function assessed by scintigraphy, 28 had a postoperative assessment, and 24 had both. Preoperative relative renal function ranged between 51% and 94% (mean 61.3%) in the higher functioning kidney. Postoperative renal function ranged from 47% to 90% (mean 60.5%) in the higher functioning kidney. A strong correlation existed between preoperative relative renal function and lateralized creatinine clearance ( P
ISSN:0090-4295
1527-9995
DOI:10.1016/S0090-4295(02)02561-X