Syndecan-1 (CD138) expression in acute myeloblastic leukemia cells: An immuno electron microscopic study

Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression in acute lymphoblastic leukemia (ALL) cells is well known: its function or presence in acute myeloblastic leukemia (AML) cells is still largely...

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Bibliographic Details
Published in:Acta oncologica 2003, Vol.42 (1), p.71-74
Main Authors: SEFTALIOGLU, Aysel, KARAKUS, Sema, DUNDAR, Semra, CAN, Belgin, ERDEMLI, Esra, KEMAL IRMAK, M, OZTAS, Emin, KORKMAZ, Cem, YAZAR, Fatih, CAVUSOGLU, Ilkin
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal
Biological and medical sciences
Bone Marrow - metabolism
Hematologic and hematopoietic diseases
Humans
Leukemia, Myeloid, Acute - metabolism
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Membrane Glycoproteins - metabolism
Microscopy, Immunoelectron
Middle Aged
Proteoglycans - metabolism
Syndecan-1
Syndecans
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Summary:Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression in acute lymphoblastic leukemia (ALL) cells is well known: its function or presence in acute myeloblastic leukemia (AML) cells is still largely unknown. The expression of syndecan-1 was studied in bone marrow biopsies of three patients with AML using electron microscopic immunocytochemistry. Positive expression of syndecan-1 was found in AML cells. These results suggest that syndecan-1 expression is not only a characteristic phenotypic marker for ALL, but is also expressed in AML cells.
ISSN:0284-186X
1651-226X
DOI:10.1080/0891060310002267