Parallel Renal and Extremity Blood Supply Abnormalities in Nonmodulation: Responses to ACE Inhibition

ABSTRACT—The aim of this work was to ascertain, in nonmodulating essential hypertension, whether the abnormality in the renal blood supply is extended to the extremities and showed a similar response to ACE inhibition and whether these abnormalities could be identified in normotensive offspring of h...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2003-04, Vol.41 (4), p.919-924
Main Authors: Sánchez, Ramiro A, Ramos, Felipe, Giannone, Carlos, Fischer, Patricia, Masnatta, Lucas, Baglivo, Hugo P, Ramírez, Agustín J, Hollenberg, Norman K
Format: Article
Language:English
Subjects:
Adult
Albuminuria - diagnosis
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Family Health
Female
Forearm - blood supply
Glomerular Filtration Rate
Humans
Hypertension - genetics
Hypertension - physiopathology
Male
Medical sciences
Plethysmography
Ramipril - pharmacology
Regional Blood Flow - drug effects
Renal Circulation - drug effects
Sodium - administration & dosage
Vascular Resistance - drug effects
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Summary:ABSTRACT—The aim of this work was to ascertain, in nonmodulating essential hypertension, whether the abnormality in the renal blood supply is extended to the extremities and showed a similar response to ACE inhibition and whether these abnormalities could be identified in normotensive offspring of hypertensives, as non-modulation is a familial process with genetic underpinnings. We measured forearm vascular blood flow (FBF) and forearm vascular resistance (FVR) by plethysmography and urinary albumin excretion in 20 normotensive without family story of hypertension (NT25±9 years), 10 modulating offspring of hypertensive parents (MHO25±6 years), 10 nonmodulating offspring of hypertensive parents (NMHO26±5 years), 12 modulating essential hypertensives (MHT34±5 years), and 11 nonmodulating essential hypertensives (NMHT32±4 years). Measurements were repeated in hypertensives after 3-month treatment with ramipril (5 mg daily). Nonmodulating individuals showed lower maximum FBF (NMHT41.96±3.3 mL/100 g per minute and NMHO35.6±9.0 mL/100 g per minute) than modulating subjects (MHT57.5±10.0 mL/100 g per minute and MHO51.8±7.0 mL/100 g per minute;P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.0000062967.90892.5D