Deactivation of Visual Transduction Without Guanosine Triphosphate Hydrolysis by G Protein

G proteins couple receptors to their target enzymes in many signal transduction cascades. It has generally been thought that deactivation of such cascades cannot occur without the hydrolysis of guanosine triphosphate (GTP) by G protein. This requirement has now been reexamined in both vertebrate and...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1992-08, Vol.257 (5074), p.1255-1258
Main Authors: Erickson, Martha A., Robinson, Phyllis, Lisman, John
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological and medical sciences
Bufo marinus
Cell physiology
Cellular signal transduction
Electrodes
Enzymes
Fundamental and applied biological sciences. Psychology
G proteins
GTP
GTP-Binding Proteins - physiology
Guanosine 5'-O-(3-Thiotriphosphate) - analogs & derivatives
Guanosine 5'-O-(3-Thiotriphosphate) - metabolism
Guanosine Triphosphate - physiology
Horseshoe Crabs
Hydrolysis
Models, Biological
Molecular and cellular biology
Nucleotides
Photoreceptor Cells - metabolism
Photoreceptors
Physiological aspects
Receptors
Retinal rods
Signal transduction
Signal Transduction - physiology
Space life sciences
Vertebrates
Vision, Ocular - physiology
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Summary:G proteins couple receptors to their target enzymes in many signal transduction cascades. It has generally been thought that deactivation of such cascades cannot occur without the hydrolysis of guanosine triphosphate (GTP) by G protein. This requirement has now been reexamined in both vertebrate and invertebrate phototransduction. Results indicate that GTP hydrolysis is not required for deactivation. Evidence is presented for an alternative model in which the target enzyme is deactivated by an inhibitory factor that is available even when GTP hydrolysis is blocked.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1519062