StuA is required for cell pattern formation in Aspergillus

The stunted (stuA) gene product is required for the orderly differentiation and spatial organization of cell types of the Aspergillus nidulans conidiophore. Expression of the stuA gene is complex. Two transcripts, stuA alpha and stuA beta, are initiated from separate promoters. Transcription of both...

Full description

Saved in:
Bibliographic Details
Published in:Genes & development 1992-09, Vol.6 (9), p.1770-1782
Main Authors: MILLER, K. Y, WU, J, MILLER, B. L
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Aspergillus - genetics
Aspergillus nidulans
Base Sequence
Biological and medical sciences
Blotting, Northern
Cloning, Molecular
Fundamental and applied biological sciences. Psychology
Fungal Proteins - chemistry
Fungal Proteins - genetics
Gene Expression Regulation, Fungal - genetics
Genes, Fungal - genetics
Genes. Genome
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Polymerase Chain Reaction
Promoter Regions, Genetic - genetics
Recombinant Fusion Proteins - chemistry
Recombinant Fusion Proteins - genetics
Transcription Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The stunted (stuA) gene product is required for the orderly differentiation and spatial organization of cell types of the Aspergillus nidulans conidiophore. Expression of the stuA gene is complex. Two transcripts, stuA alpha and stuA beta, are initiated from separate promoters. Transcription of both RNAs increases approximately 50-fold during the establishment of developmental competence. Induction-dependent transcriptional and post-transcriptional regulatory mechanisms further enhance expression 15-fold. Consistent with the latter observation, both transcripts have structural features characteristic of RNAs subject to translational control. Conidiophore morphogenesis requires regulatory interactions between the products of the stuA, bristle (brlA), and abacus (abaA) genes. Enhanced stunted expression is cell type specific and dependent on a functional BrlA protein. StuA affects the spatial localization of AbaA by acting directly, or indirectly, to repress abaA expression.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.6.9.1770