Pharmacology and clinical use of a new group of antiarrhythmic drugs: Derivatives of tricyclic nitrogen-containing systems

This paper is concerned with a new group of antiarrhythmic drugs: derivatives of phenothiazine and dibenzazepine which belong to tricyclic nitrogen-containing systems. It has been discovered that the transition from ω-aminoalkyl to ω-aminoacyl phenothiazine derivatives results in a decrease in psych...

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Bibliographic Details
Published in:Pharmacological research 1992-04, Vol.25 (3), p.217-225
Main Authors: Kaverina, Natalia V., Sokolov, Sergei F.
Format: Article
Language:English
Subjects:
Animals
Anti-Arrhythmia Agents - chemistry
Anti-Arrhythmia Agents - pharmacology
Anti-Arrhythmia Agents - therapeutic use
Antiarythmic agents
arrhythmias
Arrhythmias, Cardiac - drug therapy
Biological and medical sciences
bonnecor
Brain - drug effects
Cardiovascular system
Cell Membrane - drug effects
Dibenzazepines - chemistry
Dibenzazepines - pharmacology
Dibenzazepines - therapeutic use
ethacizine
ethmozine
Hemodynamics - drug effects
Medical sciences
Moricizine - chemistry
Moricizine - pharmacology
Moricizine - therapeutic use
Pharmacology. Drug treatments
Phenothiazines - chemistry
Phenothiazines - pharmacology
Phenothiazines - therapeutic use
supraventricular
ventricular
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Summary:This paper is concerned with a new group of antiarrhythmic drugs: derivatives of phenothiazine and dibenzazepine which belong to tricyclic nitrogen-containing systems. It has been discovered that the transition from ω-aminoalkyl to ω-aminoacyl phenothiazine derivatives results in a decrease in psychotropic activity and an increase in cardiovascular, particularly antiarrhythmic, action. Based on structural and antiarrhythmic activity studies, the new and effective drugs ethmozine, ethacizine and bonnecor have been selected and extensively studied. Data on spectra and mechanisms of their action, obtained in different arrhythmia models, have been confirmed by clinical studies. Correlation between pharmacological properties and electrophysiological mechanisms, and differences in action of the drugs studied on brain and heart plasma membrane receptors may serve as a starting point for the further directed search for new antiarrhythmic drugs among tricyclic nitrogen-containing structures.
ISSN:1043-6618
1096-1186
DOI:10.1016/S1043-6618(05)80070-2