Allergic diseases in systemic lupus erythematosus: Prevalence and immunological considerations

We attempted to obtain a deeper understanding of the relationship between systemic lupus erythematosus (SLE) and allergic diseases through comparative studies. Accordingly, we reviewed the association of both disorders and compared their immunological features based on the literature and our own fin...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2003, Vol.21 (1), p.117-121
Main Authors: SEKIGAWA, I, YOSHIIKE, T, IIDA, N, HASHIMOTO, H, OGAWA, H
Format: Article
Language:English
Subjects:
Allergic diseases
Biological and medical sciences
CD4-CD8 Ratio
General aspects
Humans
Hypersensitivity - complications
Hypersensitivity - epidemiology
Immunoglobulin E - immunology
Immunopathology
Lupus Erythematosus, Systemic - epidemiology
Lupus Erythematosus, Systemic - immunology
Medical sciences
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:We attempted to obtain a deeper understanding of the relationship between systemic lupus erythematosus (SLE) and allergic diseases through comparative studies. Accordingly, we reviewed the association of both disorders and compared their immunological features based on the literature and our own findings. Recent studies (including ours) have indicated that the risk of IgE-mediated and/or associated allergic diseases is not markedly increased in SLE patients despite their more allergic family history when compared with controls, in contrast with earlier studies. This may be related to a change of the environmental factors contributing to allergy. In addition, assessment of the immunological similarities and differences between SLE and various allergic diseases seems to be useful for understanding the relationship between them.
ISSN:0392-856X
1593-098X