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Synthesis and Evaluation of a Novel Nonsteroidal-Specific Endothelial Cell Proliferation Inhibitor
The identification of agents with specific antiproliferative or cytostatic activity against endothelial cells has significant value for the treatment of pathologies associated with angiogenesis, including solid tumors. Here, we describe a novel substituted dibenzo[b,d]pyran-6-one scaffold, exemplifi...
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| Published in: | Journal of medicinal chemistry 2003-04, Vol.46 (8), p.1289-1292 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a379t-87ac3b7cdfe1173113315f2466dce3646b9818585220c064e714d1d78816ba793 |
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| cites | cdi_FETCH-LOGICAL-a379t-87ac3b7cdfe1173113315f2466dce3646b9818585220c064e714d1d78816ba793 |
| container_end_page | 1292 |
| container_issue | 8 |
| container_start_page | 1289 |
| container_title | Journal of medicinal chemistry |
| container_volume | 46 |
| creator | Schmidt, Jonathan M Tremblay, Gilles B Pagé, Martine Mercure, Julie Feher, Miklos Dunn-Dufault, Robert Peter, Markus G Redden, Peter R |
| description | The identification of agents with specific antiproliferative or cytostatic activity against endothelial cells has significant value for the treatment of pathologies associated with angiogenesis, including solid tumors. Here, we describe a novel substituted dibenzo[b,d]pyran-6-one scaffold, exemplified by structures 9a and 10, and report preliminary in vitro activity data indicating that this scaffold is a promising lead for the development of specific inhibitors of endothelial cell proliferation. |
| doi_str_mv | 10.1021/jm034007d |
| format | article |
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Here, we describe a novel substituted dibenzo[b,d]pyran-6-one scaffold, exemplified by structures 9a and 10, and report preliminary in vitro activity data indicating that this scaffold is a promising lead for the development of specific inhibitors of endothelial cell proliferation.</description><subject>Angiogenesis Inhibitors - chemical synthesis</subject><subject>Angiogenesis Inhibitors - chemistry</subject><subject>Angiogenesis Inhibitors - pharmacology</subject><subject>Antineoplastic agents</subject><subject>Binding, Competitive</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Computer Simulation</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Estradiol - analogs & derivatives</subject><subject>Estradiol - chemistry</subject><subject>Estradiol - pharmacology</subject><subject>Estrogen Receptor alpha</subject><subject>Estrogen Receptor beta</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Models, Molecular</subject><subject>Pharmacology. 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| ispartof | Journal of medicinal chemistry, 2003-04, Vol.46 (8), p.1289-1292 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73167874 |
| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| subjects | Angiogenesis Inhibitors - chemical synthesis Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Antineoplastic agents Binding, Competitive Biological and medical sciences Cell Division - drug effects Computer Simulation Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Estradiol - analogs & derivatives Estradiol - chemistry Estradiol - pharmacology Estrogen Receptor alpha Estrogen Receptor beta General aspects Humans Medical sciences Models, Molecular Pharmacology. Drug treatments Pyrans - chemical synthesis Pyrans - chemistry Pyrans - pharmacology Receptors, Estrogen - metabolism Structure-Activity Relationship Tumor Cells, Cultured Umbilical Veins - cytology |
| title | Synthesis and Evaluation of a Novel Nonsteroidal-Specific Endothelial Cell Proliferation Inhibitor |
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