Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity

Generalized pustular psoriasis (GPP) is a rare but notoriously recalcitrant cutaneous diseases. Therefore, there have been few reports of more than ten patients with GPP who were treated at the same institution. The severity of this disease and its response to each therapeutic modality vary among pa...

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Bibliographic Details
Published in:Archives of Dermatological Research 2003-04, Vol.295 Suppl 1 (S1), p.S43-S54
Main Authors: Umezawa, Y, Ozawa, A, Kawasima, T, Shimizu, H, Terui, T, Tagami, H, Ikeda, S, Ogawa, H, Kawada, A, Tezuka, T, Igarashi, A, Harada, S
Format: Article
Language:English
Subjects:
Humans
Practice Guidelines as Topic
Psoriasis - physiopathology
Psoriasis - therapy
Severity of Illness Index
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Summary:Generalized pustular psoriasis (GPP) is a rare but notoriously recalcitrant cutaneous diseases. Therefore, there have been few reports of more than ten patients with GPP who were treated at the same institution. The severity of this disease and its response to each therapeutic modality vary among patients. In some GPP is life-threatening, but in others it may show a benign, chronic course for a long period of time. Before starting treatment, a knowledge of the therapeutic efficacy and side effects of each drug used in the treatment of GPP is necessary. In our multicenter study, we compared the effectiveness of and adverse reactions to several systemically administered drugs. Following the development of a unique classification of the disease severity based on scoring the clinical symptoms and the laboratory findings, we propose here therapeutic guidelines for the treatment of GPP.
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-002-0371-6