An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii

We have mapped the variable region of the two class 1 integrons found in the multiresistant strain Providencia stuartii 1723. Integron 1 contains a new arrangement of gene cassettes, aacA4-aadB-aadA1, conferring resistance to all aminoglycosides used for clinical treatment. Integron 2 contains a var...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2003-04, Vol.51 (4), p.787-790
Main Authors: Plante, Isabelle, Centrón, Daniela, Roy, Paul H.
Format: Article
Language:English
Subjects:
aminoglycosides
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Carboxylic Ester Hydrolases - genetics
Chromosome Mapping
DNA, Bacterial - genetics
Drug Resistance, Bacterial
Enterobacteriaceae Infections - microbiology
ereA protein
erythromycin esterase
Escherichia coli
Humans
Integrons - genetics
Medical sciences
Molecular Sequence Data
Pharmacology. Drug treatments
Providencia - enzymology
Providencia - genetics
Providencia stuartii
resistance
Reverse Transcriptase Polymerase Chain Reaction
sequencing
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Summary:We have mapped the variable region of the two class 1 integrons found in the multiresistant strain Providencia stuartii 1723. Integron 1 contains a new arrangement of gene cassettes, aacA4-aadB-aadA1, conferring resistance to all aminoglycosides used for clinical treatment. Integron 2 contains a variant of the gene cassette ere(A), coding for an erythromycin esterase, whose nucleotide sequence shares 93.7% DNA identity with ere(A) from Escherichia coli BM2195 plasmid pIP1100.
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/dkg169