Decreased red blood cell aggregation subsequent to improved glycaemic control in Type 2 diabetes mellitus

Aims Reports of rheological changes following intensification of metabolic control are limited and not concordant. The present study was designed to test the hypothesis that intensification of management of Type 2 diabetes (T2DM) with diet, exercise and insulin improves haemorheological behaviour by...

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Bibliographic Details
Published in:Diabetic medicine 2003-04, Vol.20 (4), p.301-306
Main Authors: Chong-Martinez, B., Buchanan, T. A., Wenby, R. B., Meiselman, H. J.
Format: Article
Language:English
Subjects:
Adult
Aged
aggregation
Biological and medical sciences
Blood Glucose - analysis
Blood Viscosity - physiology
diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Erythrocyte Aggregation
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Fibrinogen - analysis
Humans
Male
Medical sciences
Middle Aged
red blood cell
rheology
therapy
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Summary:Aims Reports of rheological changes following intensification of metabolic control are limited and not concordant. The present study was designed to test the hypothesis that intensification of management of Type 2 diabetes (T2DM) with diet, exercise and insulin improves haemorheological behaviour by reducing red blood cell (RBC) aggregation. Methods Blood was sampled from 55 subjects before and following 14 ± 3 weeks of intensified management. RBC aggregation was measured in vitro for cells in plasma or in an aggregating 70 kD dextran solution. Plasma viscosity and whole blood viscosity were also measured. Results During treatment, fasting glucose fell 27%, HbA1c fell 21%, and serum triglycerides and total cholesterol fell 28% and 12%, respectively (P 
ISSN:0742-3071
1464-5491
DOI:10.1046/j.1464-5491.2003.00926.x