Seasonal Variation in Copper-mediated Low-density Lipoprotein Oxidation In Vitro is Related to Varying Plasma Concentration of Oxidised Lipids in Summer and Winter

The seasonal variation of CuCl 2 -mediated low density lipoprotein (LDL) oxidation (10 &#119 M Cu 2+ , lag phase, rate of oxidation and maximum absorbance at 234 nm) were measured in 43 men and women on 4-6 occasions (mean 5.7 &#45 0.5 ) over a 12-month period. The lag phase averaged 52.7 &a...

Full description

Saved in:
Bibliographic Details
Published in:Free radical research 2003-01, Vol.37 (3), p.341-347
Main Authors: Riemersma, R.A., Wilson, R., Payne, J.A., Shepherd, M.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
alpha-Tocopherol - blood
Antioxidants
Antioxidants - metabolism
Ascorbic Acid - blood
beta Carotene - blood
Carotenoids - blood
Female
Humans
Hydroperoxy Fatty Acids
Ldl
Lipid Metabolism
Lipid Peroxidation
Lipids - blood
Lipoproteins, LDL - metabolism
Male
Middle Aged
Oxidative Susceptibility
Oxygen - metabolism
Seasonal Variation
Seasons
Sex Factors
Time Factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The seasonal variation of CuCl 2 -mediated low density lipoprotein (LDL) oxidation (10 &#119 M Cu 2+ , lag phase, rate of oxidation and maximum absorbance at 234 nm) were measured in 43 men and women on 4-6 occasions (mean 5.7 &#45 0.5 ) over a 12-month period. The lag phase averaged 52.7 &#45 0.6 min and did not differ by gender. Lag phase and rate of the rapid propagation phase of LDL oxidation showed a sinusoidal pattern over the year (increased and reduced oxidative susceptibility during January and June-July, respectively; both p
ISSN:1071-5762
1029-2470
DOI:10.1080/1071576031000061020