Suppression by Gabapentin of Pain-Related Mechano-Responses in Mice Given Orthotopic Tumor Inoculation

In this study, we examined whether several types of non-opioid agents would inhibit the pain-related responses of melanoma-bearing mice. Orthotopic inoculation with melanoma into the hind paw induced marked tactile allodynia and mechanical hyperalgesia. A peroral injection (p.o.) of gabapentin (100—...

Full description

Saved in:
Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2003, Vol.26(4), pp.550-552
Main Authors: Kuraishi, Yasushi, Iida, Yuko, Zhang, Hong-Wei, Uehara, Saori, Nojima, Hiroshi, Murata, Jun, Saiki, Ikuo, Takahata, Hiroki, Ouchi, Hidekazu
Format: Article
Language:English
Subjects:
Acetates - pharmacology
Acetates - therapeutic use
acute tolerance
Amines
analgesia
analgesic adjuvants
Animals
Biological and medical sciences
cancer pain
Cyclohexanecarboxylic Acids
Gabapentin
gamma-Aminobutyric Acid
Hyperalgesia - drug therapy
Male
Mechanoreceptors - physiology
Mechanotransduction, Cellular - drug effects
Mechanotransduction, Cellular - physiology
Medical sciences
Melanoma - complications
Melanoma - drug therapy
Mice
Mice, Inbred C57BL
morphine
Pain - drug therapy
Pain - etiology
Pain Measurement - drug effects
Pain Measurement - methods
Physical Stimulation - methods
Xenograft Model Antitumor Assays - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, we examined whether several types of non-opioid agents would inhibit the pain-related responses of melanoma-bearing mice. Orthotopic inoculation with melanoma into the hind paw induced marked tactile allodynia and mechanical hyperalgesia. A peroral injection (p.o.) of gabapentin (100—300 mg/kg) inhibited the allodynia and hyperalgesia, without effects on gross behaviors. An intraperitoneal injection (i.p.) of ketamine hydrochloride (30 mg/kg) produced partial inhibition in allodynia and hyperalgesia and prostate posture at 15 min after injection. Diclofenac sodium (10 and 30 mg/kg, i.p), mexiletine hydrochloride (20 mg/kg, i.p.), clonidine hydrochloride (0.1 mg/kg, i.p.) and suramin (100 mg/kg, i.p.) were without effects on allodynia and hyperalgesia. Subcutaneous injections of baclofen (3 mg/kg) and NG-nitro-L-arginine methyl ester (100 mg/kg) were also without effects. Repeated administration of gabapentin (150 mg/kg, p.o.) produced constant inhibitions, suggesting no analgesic tolerance. Gabapentin may be useful for the management of cancer pain.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.26.550