Adaptations in human muscle sarcoplasmic reticulum to prolonged submaximal training

• Published in: Journal of applied physiology (1985) 2003-05, Vol.94 (5), p.2034-2042
• Main Authors: Green, H. J, Ballantyne, C. S, MacDougall, J. D, Tarnopolsky, M. A, Schertzer, J. D
• Format: Article
• Language: English
• Subjects: Adaptation, Physiological - physiology; Adult; Biological and medical sciences; Blotting, Western; Calcium; Calcium-Transporting ATPases - metabolism; Exercise; Exercise - physiology; Fundamental and applied biological sciences. Psychology; Humans; Kinetics; Male; Muscle Proteins - metabolism; Muscle, Skeletal - enzymology; Muscle, Skeletal - physiology; Muscular system; Oxygen Consumption - physiology; Sarcoplasmic Reticulum - enzymology; Sarcoplasmic Reticulum - physiology; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Striated muscle. Tendons; Vertebrates: osteoarticular system, musculoskeletal system
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.00244.2002

1  Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1; and 2  Departments of Kinesiology and 3  Medicine, McMaster University, Hamilton, Ontario, Canada L8S 4K7 In this study, we employed single-leg submaximal cycle training, conducted over a 10-wk period, to investigate adaptations in sarcoplasmic reticulum (SR) Ca 2+ -regulatory proteins and processes of the vastus lateralis. During the final weeks, the untrained volunteers (age 21.4 ± 0.3 yr; means ± SE, n  = 10) were exercising 5 times/wk and for 60 min/session. Analyses were performed on tissue extracted by needle biopsy ~4 days after the last training session. Compared with the control leg, the trained leg displayed a 19% reduction ( P