Severe chronic sensory-motor polyneuropathy: coexistence of 3 unrelated etiologies in a type 1 diabetic patient. A case report and review of the literature

We present the case of a 58‐year‐old man, who has suffered from type 1 diabetes mellitus since he was young. He had monoclonal IgM kappa gammopathy of undetermined significance and high anti‐MAG antibody titer. He developed a polyneuropathic picture with the clinical and laboratory features of chron...

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Bibliographic Details
Published in:Journal of the peripheral nervous system 2003-03, Vol.8 (1), p.23-28
Main Authors: Micco, Andrea, Nobile-Orazio, Eduardo, Baron, Pierluigi, Conti, Giancarlo, Napoli, Laura, Serafini, Massimo, Scarlato, Guglielmo, Scarpini, Elio
Format: Article
Language:English
Subjects:
Chronic Disease
chronic inflammatory demyelinating polyneuropathy
diabetes mellitus
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - pathology
Diabetic Neuropathies - etiology
Diabetic Neuropathies - pathology
Humans
Male
Middle Aged
monoclonal gammopathy of undetermined significance
paraproteinemic neuropathy
Polyneuropathies - etiology
Polyneuropathies - pathology
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Summary:We present the case of a 58‐year‐old man, who has suffered from type 1 diabetes mellitus since he was young. He had monoclonal IgM kappa gammopathy of undetermined significance and high anti‐MAG antibody titer. He developed a polyneuropathic picture with the clinical and laboratory features of chronic inflammatory demyelinating polyneuropathy within the span of approximately 2 years. He benefited from IV administration of high doses of immunoglobulins. Investigation of all parameters, but particularly of the clinical phenotype, can lead to a better definition of the polyneuropathic picture, especially for therapeutic and prognostic purposes.
ISSN:1085-9489
1529-8027
DOI:10.1046/j.1529-8027.2003.03005.x