Formal Synthesis of (+)-Discodermolide

Herein we report the formal total synthesis of (+)-discodermolide in 21 steps (longest linear sequence) from commercially available Roche ester. This synthesis features the assembly of C9 - 18 and C19 - 24 fragments via a metal-chelated aldol coupling reaction.

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Bibliographic Details
Published in:Organic letters 2003-04, Vol.5 (8), p.1233-1236
Main Authors: Francavilla, Charles, Chen, Weichun, Kinder, Frederick R
Format: Article
Language:English
Subjects:
Alkanes
Animals
Antineoplastic Agents - chemical synthesis
Carbamates
Lactones - chemical synthesis
Porifera - chemistry
Pyrones
Stereoisomerism
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Description
Summary:Herein we report the formal total synthesis of (+)-discodermolide in 21 steps (longest linear sequence) from commercially available Roche ester. This synthesis features the assembly of C9 - 18 and C19 - 24 fragments via a metal-chelated aldol coupling reaction.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol034186t